246. Concave P-Stereogenic Phosphorodiamidite Ligands for Enantioselective Rh(I)-Catalysis
     Nidal Saleh, Céline Besnard, Jérôme Lacour
     Org. Lett. 2024, 26, 2202-2206

The development of a new class of concave P-stereogenic phosphorodiamidite ligands, derived from Tröger Bases (TBs), is explored. These ligands, characterized by their remarkable stability and unique structural geometry around the P-atom, are used in asymmetric Rh(I)-catalyzed additions of boronic acids to NH-isatins resulting in excellent reactivities and reasonable enantioselectivity (e.r. up to 92:8).

DOI : 10.1021/acs.orglett.4c00371 

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