198. Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam
     Oppolzer, W.; Rosset, S.; De Brabander, J.
     Tetrahedron Lett. 1997, 38, 1539-1540

A very short, 4 step synthesis of 2-(4-isobutylphenyl)propionic acid (ibuprofen) was achieved in 57% overall yield, using a highly diastereoselective alkylation of the chiral enolate derived from N-(4-isobutylphenyl)acetyl bornanesultam as a key step.

DOI : 10.1016/S0040-4039(97)00148-2 

archive ouverte unige:155663