228. M. Vuagnoux-d'Augustin, S. Kehrli, A. Alexakis,
     “Enantioselective copper catalysed conjugate addition to 2- or 3- substituted cyclopent-2-ene-1-ones: Construction of stereogenic quaternary carbon centers”
     Synlett 2007, 2057-2060.

Trimethyl- and triethylaluminum undergo enantioselective conjugate addition to 2- and 3-substituted cyclopent-2-en-1-ones in the presence of catalytic amount of a copper salt and a phosphoramidite or a diphosphite ligand. Thus, chiral quaternary centers can be built with up to 93% ee.

DOI : 10.1055/s-2007-984889 

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