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Publication 182  


  1. “New methodology for the synthesis of biologically active lactones”
    Jefford, C.W.; Jaggi, D.; Sledeski, A.W.; Boukouvalas, J.
    in Studies in Natural Products Chemistry vol 3; Atta-ur-Rahman, F. (Ed.) Elsevier: Amsterdam, 1989; Part b; p. 157-171.

New, regio- and diastereoselective processes are described in which readily accessible starting materials such as acrolein dimer and 2-trimethylsiloxyfuran are efficiently transformed into appropriately functionalized δ- and γ-lactones. Pertinent examples are provided by the syntheses of the mosquito oviposition attractant pheromone, cavernosine, epicarvernosine, eldanolide, L-factors, the "whisky" lactones, as well as other structurally related natural products.

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