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Publication 150  

  1. Efficient synthesis of imino-methano Tröger bases by nitrene insertions into C-N bonds
    Sandip A. Pujari, Laure Guénée, Jérôme Lacour
    Org. Lett. 2013, 15, 3930-3933

A direct nitrene insertion into C-N bonds is observed upon treatment of methano-Tröger bases with arylsulfonyl iminophenyliodinanes under copper and dirhodium catalysis. Novel cyclic imino-methano Tröger bases are obtained (55-88%). Enantiopure products (ee ≥ 99%) can be obtained with tailored substrates

DOI: 10.1021/ol4016892 

open archive unige:29040