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Publication 152  

  1. One-Pot Multi-Component Synthesis and Solid State Structures of Functionally Rich Polyether Macrocycles
    Mahesh Vishe, Radim Hrdina, Laure Guénée, Céline Besnard, Jérôme Lacour
    Adv. Synth. Catal. 2013, 355, 3161-3169
    [ See the Front Cover ]


Densely functionalized polyether macrocycles can be prepared in one pot in yields up to 60% by Rhodium(II)-catalyzed decomposition of methyl diazoacetate in the presence of a variety of substituted or unsaturated 5 and 6 membered ring cyclic ethers. A comprehensive analysis of the solid state conformations of the macrocyclic geometries is detailed as well as novel mechanistic insights about the multi-component condensation reaction.

DOI: 10.1002/adsc.201300462 

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