My research interests involve the development and implementation of state-of-the-art solid-state NMR methods (including hyperpolarization techniques) in combination with theoretical approaches to successfully correlate fundamental NMR interactions with their chemical activity/properties for a variety of systems ranging from nanoparticles to active pharmaceutical ingredients (APIs).
In a first time, the research focus in our group will use the expertise of studying exotic and quadrupolar NMR active nuclei to investigate weak interactions at the atomic level in bioactive compounds or APIs, in order to relate them to their chemical activity and properties.
Viger-Gravel, J.; Paruzzo, F. ; Cazaux, C. ; Jabbour, R.; Leleu, A.; Canini, F.; Florian, P.; Ronzon, F.; Gajan, D.; Lesage, A. (2020) Atomic-Scale Description of Interfaces between Antigen and Aluminum-Based Adjuvants used in Vaccines by DNP Enhanced NMR Spectroscopy, Chemistry A European Journal,
Viger-Gravel, J.; Avalos, C. E.; Kubicki, D.; Lelli, M., Ouarir, O.; Lesage, A.; Emsley, L. (2019) 19F Magic Angle Spinning Dynamic Nuclear Polarization enhanced NMR, Angew. Chem. Int. Ed., 58: 7249-7253.
Viger-Gravel, J.; Leclerc, S.; Korobkov, I.; Bryce, D. L. (2014) Direct Investigation of Halogen Bonds by Solid-State Multinuclear Magnetic Resonance Spectroscopy and Molecular Orbital Analysis. J. Am. Chem. Soc., 136: 6929-6942.