Welcome to the Winssinger Lab of Organic & Bio-Organic Chemistry
 


The overall goal of our research is to develop innovative methodologies in organic and bioorganic chemistry to address problems in biology. We are particularly interested in the use of small molecules to probe dynamic processes in biological systems. In this respect, we are developing microarray-based tools to measure enzymatic activity on a proteomic scale using small molecules designed to query the activity individual enzymes. We are also synthesising libraries of inhibitors designed based on the mechanism of specific enzyme classes or based on natural products which have been selected by evolution for specific function. We are also interested in imaging technologies to visualize biological events such as gene expression in vivo. For more information on the current projects, see Research.

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Latest Publications

  Full List    

  1. Oligonucleotide Phosphorothioates Enter Cells by Thiol-Mediated Uptake
    Q. Laurent, R. Martinent, D. Moreau, N. Winssinger, N. Sakai, S. Matile
    Angew. Chem. Int. Ed. 2021, in press
  1. Dual Bcl-XL /Bcl-2 inhibitors discovered from DNA-encoded libraries using a fragment pairing strategy
    J.-P. Daguer, A. Gonse, Y. Shchukin, L. Farrera-Soler, S. Barluenga, N. Winssinger
    Bioorg. Med. Chem. 2021, 44, 116282
  1. Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of Furanoheliangolides
    W. Liu, R. Patouret, S. Barluenga, M. Plank, R. Loewith, N. Winssinger
    ACS Cent. Sci. 2021, 7, 954-962