Welcome to the Winssinger Lab of Organic & Bio-Organic Chemistry
The overall goal of our research is to develop innovative methodologies in organic and bioorganic chemistry to address problems in biology. We are particularly interested in the use of small molecules to probe dynamic processes in biological systems. In this respect, we are developing microarray-based tools to measure enzymatic activity on a proteomic scale using small molecules designed to query the activity individual enzymes. We are also synthesising libraries of inhibitors designed based on the mechanism of specific enzyme classes or based on natural products which have been selected by evolution for specific function. We are also interested in imaging technologies to visualize biological events such as gene expression in vivo. For more information on the current projects, see Research.
Latest Publications
Full List
- Pseudo-Complementary G:C Base Pair for Mixed Sequence dsDNA Invasion and Its Applications in Diagnostics (SARS-CoV-2 Detection)
M. López-Tena, L. Farrera-Soler, S. Barluenga, N. Winssinger
JACS Au 2023, 3, 449-458
- DNA-Encoded Libraries: Towards Harnessing their Full Power with Darwinian Evolution
M. Dockerill, N. Winssinger
Angew. Chem. Int. Ed. 2023, 62, e202215542
- Two-Helix Supramolecular Proteomimetic Binders Assembled via PNA-Assisted Disulfide Crosslinking
M. Imiołek, N. Winssinger
ChemBioChem 2023, 24, e202200561