Welcome to the Winssinger Lab of Organic & Bio-Organic Chemistry

The overall goal of our research is to develop innovative methodologies in organic and bioorganic chemistry to address problems in biology. We are particularly interested in the use of small molecules to probe dynamic processes in biological systems. In this respect, we are developing microarray-based tools to measure enzymatic activity on a proteomic scale using small molecules designed to query the activity individual enzymes. We are also synthesising libraries of inhibitors designed based on the mechanism of specific enzyme classes or based on natural products which have been selected by evolution for specific function. We are also interested in imaging technologies to visualize biological events such as gene expression in vivo. For more information on the current projects, see Research.

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Latest Publications

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  1. Photocatalysis in Chemical Biology: Extending the Scope of Optochemical Control and Towards New Frontiers in Semisynthetic Bioconjugates and Biocatalysis
    N. Winssinger, W. Liu, E. Watson
    Helv. Chim. Acta 2021, in press
  1. Synthesis of α-exo-Methylene-γ-butyrolactones: Recent Developments and Applications in Natural Product Synthesis
    W. Liu, N. Winssinger
    Synthesis 2021, 53, 3977-3990
  1. SARS-COV2- infection as a trigger of humoral response against apolipoprotein A-1
    S. Pagano, S. Yerly, B. Meyer, C. Juillard, N. Suh, C. Le Terrier, J.-P. Daguer, L. Farrera-Soler, S. Barluenga, G. Piumatti, O. Hartley, B. Lemaitre, C. S. Eberhardt, C.-A. Siegrist, I. Eckerle, S. Stringhini, I. Guessous, L. Kaiser, J. Pugin, N. Winssinger, N. Vuilleumier
    Atherosclerosis 2021, 331, e78