Welcome to the Winssinger Lab of Organic & Bio-Organic Chemistry
 


The overall goal of our research is to develop innovative methodologies in organic and bioorganic chemistry to address problems in biology. We are particularly interested in the use of small molecules to probe dynamic processes in biological systems. In this respect, we are developing microarray-based tools to measure enzymatic activity on a proteomic scale using small molecules designed to query the activity individual enzymes. We are also synthesising libraries of inhibitors designed based on the mechanism of specific enzyme classes or based on natural products which have been selected by evolution for specific function. We are also interested in imaging technologies to visualize biological events such as gene expression in vivo. For more information on the current projects, see Research.

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Latest Publications

  Full List    

  1. Small-molecule modulators of the ATPase VCP/p97 affect specific p97 cellular functions
    A. Figuerola-Conchas, J. Saarbach, J.-P. Daguer, A. Cieren, S. Barluenga, N. Winssinger, M. Gotta
    ACS Chem. Biol. 2019, in press
  1. Probing for Thiol-Mediated Uptake into Bacteria
    Q. Laurent, M. Berthet, Y. Cheng, N. Sakai, S. Barluenga, N. Winssinger, S. Matile
    ChemBioChem 2019, in press
  1. Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules
    K. T. Kim, S. Angerani, D. Chang, N. Winssinger
    J. Am. Chem. Soc. 2019, 141, 16288-16295