Department of organic chemistry Department of organic chemistry

Welcome to the Winssinger Lab of Organic & Bio-Organic Chemistry
 


The overall goal of our research is to develop innovative methodologies in organic and bioorganic chemistry to address problems in biology. We are particularly interested in the use of small molecules to probe dynamic processes in biological systems. In this respect, we are developing microarray-based tools to measure enzymatic activity on a proteomic scale using small molecules designed to query the activity individual enzymes. We are also synthesising libraries of inhibitors designed based on the mechanism of specific enzyme classes or based on natural products which have been selected by evolution for specific function. We are also interested in imaging technologies to visualize biological events such as gene expression in vivo. For more information on the current projects, see Research.

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Latest Publications

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  1. Combining recombinase polymerase amplification and DNA-templated reaction for SARS-CoV-2 sensing with dual fluorescence and lateral flow assay output
    L. Farrera-Soler, A. Gonse, K. T. Kim, S. Barluenga, N. Winssinger
    Biopolymers, in press
  1. Biosupramolecular networks: Taking inspiration from nature to create powerful synthetic platforms
    E. E. Watson, N. Winssinger
    Curr. Opin. Chem. Biol. 2022, 66, 102104
  1. A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic molecules
    B. R. Vummidi, L. Farrera-Soler, J.-P. Daguer, M. Dockerill, S. Barluenga, N. Winssinger
    Nat. Chem., in press

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