Publications

 


  1. Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma
    L. Farrera, J.-P. Daguer, S. Barluenga, P. R. Cohen, S. Pagano, S. Yerly, L. Kaiser, N. Vuilleumier, N. Winssinger
    medRxiv 2020, in press
  1. Sense-and-release Logic-gated Molecular Network Responding to Dimeric Cell Surface Proteins
    S. Angerani, N. Winssinger
    J. Am. Chem. Soc. 2020, 142, 12333-12340
  1. Kilian Muñiz (1970-2020)
    J. Streuff, A. M. Echavarren, J. M. González, M. Oestreich, A. Gansäuer, S. Barluenga, N. Winssinger
    Angew. Chem. Int. Ed. 2020, 59, 7648
  1. PNA-Based Dynamic Combinatorial Libraries (PDCL) and screening of lectins
    L. Farrera-Soler, J.-P. Daguer, P. Raunft, S. Barluenga, A. Imberty, N. Winssinger
    Bioorg. Med. Chem. 2020, 28, 115458
  1. Enhanced SNP-sensing using DNA-templated reactions through confined hybridization of minimal substrates (CHOMS)
    K. T. Kim, N. Winssinger
    Chem. Sci. 2020, 11, 4150-4157
  1. Smartphone DNA or RNA-Sensing Using Semisynthetic Luciferase-Based Logic Device
    D. Chang, K. T. Kim, E. Lindberg, N. Winssinger
    ACS Sens. 2020, 5, 807-813
  1. Cell-Penetrating Streptavidin:  A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems such as Adaptive Benzopolysulfane Networks
    J. López-Andarias, J. Saarbach, D. Moreau, Y. Cheng, E. Derivery, Q. Laurent, M. González-Gaitán, N. Winssinger, N. Sakai, S. Matile
    J. Am. Chem. Soc. 2020, 142, 4784-4792
  1. Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9
    M. Plank, M. Perepelkina, M. Müller, S. Vaga, X. Zou, C. Bourgoint, M. Berti, J. Saarbach, S. Haesendonckx, N. Winssinger, R. Aebersold, R. Loewith
    Mol. Cell. Proteomics 2020, 19, 655-671
  1. Caprin-1 Promotes Cellular Uptake of Nucleic Acids with Backbone and Sequence Discrimination
    V. Galli, K. K. Sadhu, D. Masi, J. Saarbach, A. Roux, N. Winssinger
    Helv. Chim. Acta 2020, 103, e1900255
  1. Small-molecule modulators of the ATPase VCP/p97 affect specific p97 cellular functions
    A. Figuerola-Conchas, J. Saarbach, J.-P. Daguer, A. Cieren, S. Barluenga, N. Winssinger, M. Gotta
    ACS Chem. Biol. 2020, 15, 243-253
  1. Probing for Thiol-Mediated Uptake into Bacteria
    Q. Laurent, M. Berthet, Y. Cheng, N. Sakai, S. Barluenga, N. Winssinger, S. Matile
    ChemBioChem 2020, 21, 69-73
  1. Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules
    K. T. Kim, S. Angerani, D. Chang, N. Winssinger
    J. Am. Chem. Soc. 2019, 141, 16288-16295
  1. Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics
    J. Saarbach, P. M. Sabale, N. Winssinger
    Curr. Opin. Chem. Biol. 2019, 52, 112-124
  1. Luciferase-Induced Photouncaging: Bioluminolysis
    D. Chang, E. Lindberg, S. Feng, S. Angerani, H. Riezman, N. Winssinger
    Angew. Chem. Int. Ed. 2019, 58, 16033-16037
  1. Sphingolipids and membrane targets for therapeutics
    R. Loewith, H. Riezman, N. Winssinger
    Curr. Opin. Chem. Biol. 2019, 50, 19-28
  1. Visible Light Photoredox Catalysis Using Ruthenium Complexes in Chemical Biology
    S. Angerani, N. Winssinger
    Chem. Eur. J. 2019, 25, 6661-6672
  1. Lysosome-targeted photoactivation reveals local sphingosine metabolism signatures
    S. Feng, T. Harayama, D. Chang, J. T. Hannich, N. Winssinger, H. Riezman
    Chem. Sci. 2019, 10, 2253-2258
  1. Turn On of a Ruthenium(II) Photocatalyst by DNA-Templated Ligation
    M. Anzola, N. Winssinger
    Chem. Eur. J. 2019, 25, 334-342
  1. Bioorthogonal Chemistry
    N. Winssinger
    CHIMIA 2018, 72, 755
  1. Editorial overview: Synthetic biomolecules
    R. J. Payne, N. Winssinger
    Curr. Opin. Chem. Biol. 2018, 46, A3-A4
  1. Luciferase-induced photoreductive uncaging of small-molecule effectors
    E. Lindberg, S. Angerani, M. Anzola, N. Winssinger
    Nat. Commun. 2018, 9, art. 3539
  1. Rapid and scalable synthesis of chiral bromolactones as precursors to α-exo-methylene-γ-butyrolactone-containing sesquiterpene lactones
    R. Lagoutte, M. Pastor, M. Berthet, N. Winssinger
    Tetrahedron 2018, 74, 6012-6021
  1. Ruthenium-based Photocatalysis in Templated Reactions
    J. Saarbach, E. Lindberg, N. Winssinger
    CHIMIA 2018, 72, 207-211
  1. Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function
    S. Feng, T. Harayama, S. Montessuit, F. P. A. David, N. Winssinger, J.-C. Martinou, H. Riezman
    eLife 2018, 7, e34555
  1. Editorial - Biography of Professor Nicolaou: a journey to the extremes of molecular complexity
    N. Winssinger
    J. Antibiot. 2018, 71, 149-150
  1. Double-Stranded RNA-specific Templated Reaction with Triplex Forming PNA
    K. T. Kim, D. Chang, N. Winssinger
    Helv. Chim. Acta 2018, 101, e170095
  1. Accelerating Turnover Frequency in Nucleic Acid Templated Reactions
    D. Chang, K. T. Kim, E. Lindberg, N. Winssinger
    Bioconjugate Chem. 2018, 29, 158-163
  1. Peptide nucleic acid-templated selenocystine–selenoester ligation enables rapid miRNA detection
    J. Sayers, R. J. Payne, N. Winssinger
    Chem. Sci. 2018, 9, 896-903
  1. Synthesis of deoxyelephantopin analogues
    R. Lagoutte, C. Serba, N. Winssinger
    J. Antibiot. 2018, 71, 248-256
  1. Following the Lead from Nature with Covalent Inhibitors
    R. Lagoutte, N. Winssinger
    CHIMIA 2017, 71, 703-711
  1. Facile access to modified and functionalized PNAs through Ugi-based solid phase oligomerization
    J. Saarbach, D. Masi, C. Zambaldo, N. Winssinger
    Bioorg. Med. Chem. 2017, 25, 5171-5177
  1. Covalent inhibitors: an opportunity for rational target selectivity
    R. Lagoutte, R. Patouret, N. Winssinger
    Curr. Opin. Chem. Biol. 2017, 39, 54-63
  1. Kinase-templated abiotic reaction
    J. Saarbach, E. Lindberg, S. Folliet, S. Georgeon, O. Hantschel, N. Winssinger
    Chem. Sci. 2017, 8, 5119-5125
  1. Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells
    T. Machida, A. Novoa, É. Gillon, S. Zheng, J. Claudinon, T. Eierhoff, A. Imberty, W. Römer, N. Winssinger
    Angew. Chem. Int. Ed. 2017, 56, 6762-6766
  1. Critical Analysis of Rate Constants and Turnover Frequency in Nucleic Acid-Templated Reactions: Reaching Terminal Velocity
    D. Chang, E. Lindberg, N. Winssinger
    J. Am. Chem. Soc. 2017, 139, 1444-1447
  1. Activation of Cell-Penetrating Peptides with Ionpair-π Interactions and Fluorophiles
    N. Chuard, K. Fujisawa, P. Morelli, J. Saarbach, N. Winssinger, P. Metrangolo, G. Resnati, N. Sakai, S. Matile
    J. Am. Chem. Soc. 2016, 138, 11264-11271
  1. Divergent synthesis and identification of the cellular targets of deoxyelephantopins
    R. Lagoutte, C. Serba, D. Abegg, D. G. Hoch, A. Adibekian, N. Winssinger
    Nat. Commun. 2016, 7, 12470
  1. Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization
    T. Machida, S. Dutt, N. Winssinger
    Angew. Chem. Int. Ed. 2016, 55, 8595-8598
  1. High Spatial Resolution Imaging of Endogenous Hydrogen Peroxide in Living Cells by Solid-state Fluorescence
    E. Lindberg, N. Winssinger
    ChemBioChem 2016, 17, 1612-1615
  1. A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer
    L. Kinzel, A. Ernst, M. Orth, V. Albrecht, R. Hennel, N. Brix, B. Frey, U. S. Gaipl, G. Zuchtriegel, C. A. Reichel, A. Blutke, D. Schilling, G. Multhoff, M. Li, M. Niyazi, A. A. Friedl, N. Winssinger, C. Belka, K. Lauber
    Oncotarget 2016, 7, 43199-43219
  1. Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties
    C. Zambaldo, J.-P. Daguer, J. Saarbach, S. Barluenga, N. Winssinger
    MedChemComm 2016, 7, 1340-1351
  1. Nucleic Acid Templated Chemical Reaction in a Live Vertebrate
    L. Holtzer, I. Oleinich, M. Anzola, E. Lindberg, K. K. Sadhu, M. Gonzalez-Gaitan, N. Winssinger
    ACS Cent. Sci. 2016, 2, 394-400
  1. One-Step Derivatization of Reducing Oligosaccharides for Rapid and Live-Cell Compatible Chelation-Assisted CuAAC Conjugation
    T. Machida, N. Winssinger
    ChemBioChem 2016, 17, 811-815
  1. Rapid and Scalable Synthesis of cis-Fused Guaiane-Type Sesquiterpenes
    C. Serba, R. Lagoutte, N. Winssinger
    Eur. J. Org. Chem. 2016, 644-646
  1. Novel PTP1B inhibitors identified by DNA display of fragment pairs
    S. Barluenga, C. Zambaldo, H. A. Ioannidou, M. Ciobanu, P. Morieux, J.-P. Daguer, N. Winssinger
    Bioorg. Med. Chem. Lett. 2016, 26, 1080-1085
  1. Duplex formation and secondary structure of γ-PNA observed by NMR and CD
    J. M. P. Viéville, S. Barluenga, N. Winssinger, M.-A. Delsuc
    Biophys. Chem. 2016, 210, 9-13
  1. In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis
    K. K. Sadhu, E. Lindberg, N. Winssinger
    Chem. Commun. 2015, 51, 16664-16666
  1. HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas
    A. Ernst, H. Anders, H. Kapfhammer, M. Orth, R. Hennel, K. Seidl, N. Winssinger, C. Belka, S. Unkel, K. Lauber
    Cancer Lett. 2015, 365, 211-222
  1. DNA display of glycoconjugates to emulate oligomeric interactions of glycans
    A. Novoa, N. Winssinger
    Beilstein J. Org. Chem. 2015, 11, 707-719
  1. PNA as a Biosupramolecular Tag for Programmable Assemblies and Reactions
    S. Barluenga, N. Winssinger
    Acc. Chem. Res. 2015, 48, 1319-1331
  1. Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene
    T. Machida, K. Lang, L. Xue, J. W. Chin, N. Winssinger
    Bioconjugate Chem. 2015, 26, 802-806
  1. Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules
    J.-P. Daguer, C. Zambaldo, D. Abegg, S. Barluenga, C. Tallant, S. Müller, A. Adibekian, N. Winssinger
    Angew. Chem. Int. Ed. 2015, 54, 6057-6061
  1. PNA-encoded chemical libraries
    C. Zambaldo, S. Barluenga, N. Winssinger
    Curr. Opin. Chem. Biol. 2015, 26, 8-15
  1. DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
    J.-P. Daguer, C. Zambaldo, M. Ciobanu, P. Morieux, S. Barluenga, N. Winssinger
    Chem. Sci. 2015, 6, 739-744
  1. PNA-Encoded Synthesis (PES) of a 10 000-Member Hetero-Glycoconjugate Library and Microarray Analysis of Diverse Lectins
    A. Novoa, T. Machida, S. Barluenga, A. Imberty, N. Winssinger
    ChemBioChem 2014, 15, 2058-2065
  1. A LecA Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion by Pseudomonas aeruginosa
    A. Novoa, T. Eierhoff, J. Topin, A. Varrot, S. Barluenga, A. Imberty, W. Römer, N. Winssinger
    Angew. Chem. Int. Ed. 2014, 53, 8885-8889
  1. Rapid miRNA Imaging in Cells Using Fluorogenic Templated Staudinger Reaction Between PNA-Based Probes
    K. Gorska, N. Winssinger
    in Peptide Nucleic Acids; P. E. Nielsen, and D. H. Appella (Eds.)Methods in Molecular Biology, Vol. 1050; Humana Press, 2014; (Methods and Protocols, Second Edition); p. 179-192
  1. Assembly of PNA-Tagged Small Molecules, Peptides, and Carbohydrates onto DNA Templates: Programming the Combinatorial Pairing and Inter-ligand Distance
    N. Winssinger, K. Gorska, M. Ciobanu, J. P. Daguer, S. Barluenga
    in Peptide Nucleic Acids; P. E. Nielsen, and D. H. Appella (Eds.)Methods in Molecular Biology, Vol. 1050; Humana Press, 2014; (Methods and Protocols, Second Edition); p. 95-110
  1. Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway
    V. Duplan, C. Serba, J. Garcia, G. Valot, S. Barluenga, M. Hoerlé, M. Cuendet, N. Winssinger
    Org. Biomol. Chem. 2014, 12, 370-375
  1. Nucleic Acid-tagged Peptides: Encoding Libraries and Controlling Dimerization and Conformation
    K. K. Sadhu, N. Winssinger
    CHIMIA 2013, 67, 905-909
  1. Picture Perfect: DNA-Templated Photoaffinity Labeling
    S. Barluenga, N. Winssinger
    ChemBioChem 2013, 14, 1927-1928
  1. Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates
    A. Novoa, S. Barluenga, C. Serba, N. Winssinger
    Chem. Commun. 2013, 49, 7608-7610
  1. Reactions Templated by Nucleic Acids: More Ways to Translate Oligonucleotide-Based Instructions into Emerging Function
    K. Gorska, N. Winssinger
    Angew. Chem. Int. Ed. 2013, 52, 6820-6843
  1. Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis
    C. Serba, N. Winssinger
    Eur. J. Org. Chem. 2013, 4195-4214
  1. Nucleic Acid-programmed Assemblies: Translating Instruction into Function in Chemical Biology
    N. Winssinger
    CHIMIA 2013, 67, 340-348
  1. Detection of miRNA in Live Cells by Using Templated RuII-Catalyzed Unmasking of a Fluorophore
    K. K. Sadhu, N. Winssinger
    Chem. Eur. J. 2013, 19, 8182-8189
  1. Selective affinity-based probe for oncogenic kinases suitable for live cell imaging
    C. Zambaldo, K. K. Sadhu, G. Karthikeyan, S. Barluenga, J.-P. Daguer, N. Winssinger
    Chem. Sci. 2013, 4, 2088-2092
  1. DNA as a Platform to Program Assemblies with Emerging Functions in Chemical Biology
    K. K. Sadhu, M. Röthlingshöfer, N. Winssinger
    Isr. J. Chem. 2013, 53, 75-86
  1. Self-Assembled Antibody Multimers through Peptide Nucleic Acid Conjugation
    S. A. Kazane, J. Y. Axup, C. H. Kim, M. Ciobanu, E. D. Wold, S. Barluenga, B. A. Hutchins, P. G. Schultz, N. Winssinger, V. V. Smider
    J. Am. Chem. Soc. 2013, 135, 340-346
  1. Photoreductive Uncaging of Fluorophore in Response to Protein Oligomers by Templated Reaction in Vitro and in Cellulo
    K. K. Sadhu, T. Eierhoff, W. Römer, N. Winssinger
    J. Am. Chem. Soc. 2012, 134, 20013-20016
  1. Expanding the Scope of PNA-Encoded Synthesis (PES): Mtt-Protected PNA Fully Orthogonal to Fmoc Chemistry and a Broad Array of Robust Diversity-Generating Reactions
    D. Chouikhi, M. Ciobanu, C. Zambaldo, V. Duplan, S. Barluenga, N. Winssinger
    Chem. Eur. J. 2012, 18, 12698-12704
  1. DNA display of PNA-tagged ligands: A versatile strategy to screen libraries and control geometry of multidentate ligands
    N. Winssinger
    Artif. DNA PNA XNA 2012, 3, 1-4
  1. Asymmetric Synthesis of Pochonin E and F, Revision of Their Proposed Structure, and Their Conversion to Potent Hsp90 Inhibitors
    G. Karthikeyan, C. Zambaldo, S. Barluenga, V. Zoete, M. Karplus, N. Winssinger
    Chem. Eur. J. 2012, 18, 8978-8986
  1. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis
    G. Valot, J. Garcia, V. Duplan, C. Serba, S. Barluenga, N. Winssinger
    Angew. Chem. Int. Ed. 2012, 51, 5391-5394
  1. Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries
    J.-P. Daguer, M. Ciobanu, S. Barluenga, N. Winssinger
    Org. Biomol. Chem. 2012, 10, 1502-1505
  1. Nucleic Acid Templated Uncaging of Fluorophores Using Ru-Catalyzed Photoreduction with Visible Light
    M. Röthlingshöfer, K. Gorska, N. Winssinger
    Org. Lett. 2012, 14, 482-485
  1. Polyubiquitination of Transforming Growth Factor β (TGFβ)-associated Kinase 1 Mediates Nuclear Factor-κB Activation in Response to Different Inflammatory Stimuli
    A. Hamidi, V. von Bulow, R. Hamidi, N. Winssinger, S. Barluenga, C.-H. Heldin, M. Landstrom
    J. Biol. Chem. 2012, 287, 123-133
  1. Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions
    J. Garcia, S. Barluenga, K. Gorska, F. Sasse, N. Winssinger
    Bioorg. Med. Chem. 2012, 20, 672-680
  1. Nucleic Acid-Templated Energy Transfer Leading to a Photorelease Reaction and its Application to a System Displaying a Nonlinear Response
    M. Röthlingshöfer, K. Gorska, N. Winssinger
    J. Am. Chem. Soc. 2011, 133, 18110-18113
  1. Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells
    M. Ciobanu, K.-T. Huang, J.-P. Daguer, S. Barluenga, O. Chaloin, E. Schaeffer, C. G. Mueller, D. A. Mitchell, N. Winssinger
    Chem. Commun. 2011, 47, 9321-9323
  1. Rapid fluorescence imaging of miRNAs in human cells using templated Staudinger reaction
    K. Gorska, I. Keklikoglou, U. Tschulena, N. Winssinger
    Chem. Sci. 2011, 2, 1969-1975
  1. Translating instructions into function by nucleic acid programmed self-assembly
    N. Winssinger
    Actual. Chim. 2011, 42-48
  1. Cysteine Mapping in Conformationally Distinct Kinase Nucleotide Binding Sites: Application to the Design of Selective Covalent Inhibitors
    E. Leproult, S. Barluenga, D. Moras, J.-M. Wurtz, N. Winssinger
    J. Med. Chem. 2011, 54, 1347-1355
  1. DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker
    K. Gorska, A. Manicardi, S. Barluenga, N. Winssinger
    Chem. Commun. 2011, 47, 4364-4366
  1. DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles
    J. P. Daguer, M. Ciobanu, S. Alvarez, S. Barluenga, N. Winssinger
    Chem. Sci. 2011, 2, 625-632
  1. Combinatorial Self-Assembly of Glycan Fragments into Microarrays
    K.-T. Huang, K. Gorska, S. Alvarez, S. Barluenga, N. Winssinger
    ChemBioChem 2011, 12, 56-60
  1. The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse
    I. Grad, C. R. Cederroth, J. Walicki, C. Grey, S. Barluenga, N. Winssinger, B. De Massy, S. Nef, D. Picard, S. Rutherford
    PLoS ONE 2010, 5, e15770
  1. Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions
    K. Gorska, J. Beyrath, S. Fournel, G. Guichard, N. Winssinger
    Chem. Commun. 2010, 46, 7742-7744
  1. The Novel Hsp90 Inhibitor NXD30001 Induces Tumor Regression in a Genetically Engineered Mouse Model of Glioblastoma Multiforme
    H. Zhu, S. Woolfenden, R. T. Bronson, Z. M. Jaffer, S. Barluenga, N. Winssinger, A. E. Rubenstein, R. Chen, A. Charest
    Mol. Can. Ther. 2010, 9, 2618-2626
  1. Autoactivation of Transforming Growth Factor β-activated Kinase 1 Is a Sequential Bimolecular Process
    R. Scholz, C. L. Sidler, R. F. Thali, N. Winssinger, P. C. F. Cheung, D. Neumann
    J. Biol. Chem. 2010, 285, 25753-25766
  1. Metathesis Reactions in Solid-Phase Organic Synthesis
    S. Barluenga, P.-Y. Dakas, R. Jogireddy, G. Valot, N. Winssinger
    in Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts; J. Cossy, S. Arseniyadis, and C. Meyer (Eds.)Wiley-VCH, 2010; Section 13; p. 349-372
  1. Selection of bead-displayed, PNA-encoded chemicals
    N. R. Gassman, J. P. Nelli, S. Dutta, A. Kuhn, K. Bonin, Z. Pianowski, N. Winssinger, M. Guthold, J. C. Macosko
    J. Mol. Recognit. 2010, 23, 414-422
  1. Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation
    A. Broggini-Tenzer, A. Hollenstein, Z. Pianowski, A. Wampfler, P. Furmanova, N. Winssinger, M. Pruschy
    Proteomics 2010, 10, 304-314
  1. Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action
    J. Garcia, S. Barluenga, K. Beebe, L. Neckers, N. Winssinger
    Chem. Eur. J. 2010, 16, 9767-9771
  1. In Vivo Efficacy of Natural Product-Inspired Irreversible Kinase Inhibitors
    S. Barluenga, R. Jogireddy, G. K. Koripelly, N. Winssinger
    Chem. Bio. Chem. 2010, 11, 1692-1699
  1. Clickable peptide nucleic acids (cPNA) with tunable affinity
    D. Chouikhi, S. Barluenga, N. Winssinger
    Chem. Commun. 2010, 46, 5476-5478
  1. Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL
    R. Jogireddy, S. Barluenga, N. Winssinger
    ChemMedChem 2010, 5, 670-673
  1. Hsp90 Inhibition with Resorcylic Acid Lactones (RALs)
    N. Winssinger, J.-G. Fontaine, S. Barluenga
    Curr. Top. Med. Chem. 2009, 9, 1419-1435
  1. Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights
    S. Barluenga, J.-G. Fontaine, C. Wang, K. Aouadi, R. Chen, K. Beebe, L. Neckers, N. Winssinger
    ChemBioChem 2009, 10, 2753-2759
  1. Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases
    R. Jogireddy, P.-Y. Dakas, G. Valot, S. Barluenga, N. Winssinger
    Chem. Eur. J. 2009, 15, 11498-11506
  1. Divergent Syntheses of Resorcylic Acid Lactones: L-783277, LL-Z1640-2, and Hypothemycin
    P.-Y. Dakas, R. Jogireddy, G. Valot, S. Barluenga, N. Winssinger
    Chem. Eur. J. 2009, 15, 11490-11497
  1. DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV
    K. Gorska, K.-T. Huang, O. Chaloin, N. Winssinger
    Angew. Chem. Int. Ed. 2009, 48, 7695-7700
  1. Imaging of mRNA in Live Cells Using Nucleic Acid-Templated Reduction of Azidorhodamine Probes
    Z. Pianowski, K. Gorska, L. Oswald, C. A. Merten, N. Winssinger
    J. Am. Chem. Soc. 2009, 131, 6492-6497
  1. The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts
    M. Spichty, A. Taly, F. Hagn, H. Kessler, S. Barluenga, N. Winssinger, M. Karplus
    Biophys. Chem. 2009, 143, 111-123
  1. Synthesis of pochoxime prodrugs as potent HSP90 inhibitors
    C. Wang, S. Barluenga, G. K. Koripelly, J.-G. Fontaine, R. Chen, J.-C. Yu, X. Shen, J. C. Chabala, J. V. Heck, A. Rubenstein, N. Winssinger
    Bioorg. Med. Chem. Lett. 2009, 19, 3836-3840
  1. Self-Assembly of PNA-Encoded Peptides into Microarrays
    F. Debaene, N. Winssinger
    in Peptide Microarrays: Methods and Protocols; M. Cretich, and M. Chiari (Eds.)Methods in Molecular Biology, Vol. 570; Humana Press, 2009; Part 3, Chap. 15; p. 299-307
  1. High-Throughput Synthesis of Natural Products
    N. Winssinger, S. Barluenga, P.-Y. Dakas
    in The Power of Functional Resins in Organic Synthesis; J. Tulla-Puche, and F. Albericio (Eds.)Wiley-VCH, 2009; Chapter 21; p. 613-640
  1. Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential
    S. Barluenga, P.-Y. Dakas, M. Boulifa, E. Moulin, N. Winssinger
    C. R. Chimie 2008, 11, 1306-1317
  1. Expanding the Scope and Orthogonality of PNA Synthesis
    S. Pothukanuri, Z. Pianowski, N. Winssinger
    Eur. J. Org. Chem. 2008, 3141-3148
  1. Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents
    D. García-Cuadrado, S. Barluenga, N. Winssinger
    Chem. Commun. 2008, 4619-4621
  1. Chemical Technologies: Probing Biology with Small Molecules
    N. Winssinger, Z. Pianowski, S. Barluenga
    in Chemical and Functional Genomic Approaches to Stem Cell Biology and Regenerative Medicine; S. Ding (Ed.)Wiley, 2008; Chap. 5; p. 109-144
  1. Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor
    S. Barluenga, C. Wang, J.-G. Fontaine, K. Aouadi, K. Beebe, S. Tsutsumi, L. Neckers, N. Winssinger
    Angew. Chem. Int. Ed. 2008, 47, 4432-4435
  1. Nucleic acid encoding to program self-assembly in chemical biology
    Z. L. Pianowski, N. Winssinger
    Chem. Soc. Rev. 2008, 37, 1330-1336
  1. Fluorescence-based detection of single nucleotide permutation in DNA via catalytically templated reaction
    Z. L. Pianowski, N. Winssinger
    Chem. Commun. 2007, 3820-3822
  1. Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors
    P.-Y. Dakas, S. Barluenga, F. Totzke, U. Zirrgiebel, N. Winssinger
    Angew. Chem. Int. Ed. 2007, 46, 6899-6902
  1. Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases
    F. Debaene, J. A. Da Silva, Z. Pianowski, F. J. Duran, N. Winssinger
    Tetrahedron 2007, 63, 6577-6586
  1. A Highly Efficient Azide-Based Protecting Group for Amines and Alcohols
    S. Pothukanuri, N. Winssinger
    Org. Lett. 2007, 9, 2223-2225
  1. IPy2BF4-Mediated Glycosylation and Glycosyl Fluoride Formation
    K.-T. Huang, N. Winssinger
    Eur. J. Org. Chem. 2007, 2007, 1887-1890
  1. Probing Biology with Small Molecule Microarrays (SMM)
    N. Winssinger, Z. Pianowski, F. Debaene
    in Combinatorial Chemistry on Solid Supports; S. Bräse (Ed.)Topics in Current Chemistry, Vol. 278; Springer, 2007; p. 311-342
  1. Chemistry and biology of resorcylic acid lactones
    N. Winssinger, S. Barluenga
    Chem. Commun. 2007, 22-36
  1. Self-Assembled Small-Molecule Microarrays for Protease Screening and Profiling
    H. D. Urbina, F. Debaene, B. Jost, C. Bole-Feysot, D. E. Mason, P. Kuzmic, J. L. Harris, N. Winssinger
    ChemBioChem 2006, 7, 1790-1797
  1. Diversity-Oriented Synthesis of Pochonins and Biological Evaluation against a Panel of Kinases
    E. Moulin, S. Barluenga, F. Totzke, N. Winssinger
    Chem. Eur. J. 2006, 12, 8819-8834
  1. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold
    S. Barluenga, P.-Y. Dakas, Y. Ferandin, L. Meijer, N. Winssinger
    Angew. Chem. Int. Ed. 2006, 45, 3951-3954
  1. Concise Synthesis of Pochonin A, an HSP90 Inhibitor
    E. Moulin, S. Barluenga, N. Winssinger
    Org. Lett. 2005, 7, 5637-5639
  1. Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries
    N. Winssinger, J. L. Harris
    Expert Rev. Proteomics 2005, 2, 937-947
  1. PNA Encoding (PNA=peptide nucleic acid): From Solution-Based Libraries to Organized Microarrays
    J. L. Harris, N. Winssinger
    Chem. Eur. J. 2005, 11, 6792-6801
  1. Solution- and Solid-Phase Synthesis of Radicicol (Monorden) and Pochonin C
    S. Barluenga, E. Moulin, P. Lopez, N. Winssinger
    Chem. Eur. J. 2005, 11, 4935-4952
  1. Design, Synthesis, and Biological Evaluation of HSP90 Inhibitors Based on Conformational Analysis of Radicicol and Its Analogues
    E. Moulin, V. Zoete, S. Barluenga, M. Karplus, N. Winssinger
    J. Am. Chem. Soc. 2005, 127, 6999-7004
  1. Activity Profile of Dust Mite Allergen Extract Using Substrate Libraries and Functional Proteomic Microarrays
    J. Harris, D. E. Mason, J. Li, K. W. Burdick, B. J. Backes, T. Chen, A. Shipway, G. Van Heeke, L. Gough, A. Ghaemmaghami, F. Shakib, F. Debaene, N. Winssinger
    Chem. Biol. 2004, 11, 1361-1372
  1. PNA-Encoded Protease Substrate Microarrays
    N. Winssinger, R. Damoiseaux, D. C. Tully, B. H. Geierstanger, K. Burdick, J. L. Harris
    Chem. Biol. 2004, 11, 1351-1360
  1. Development of a Functionalized Xenon Biosensor
    M. M. Spence, E. J. Ruiz, S. M. Rubin, T. J. Lowery, N. Winssinger, P. G. Schultz, D. E. Wemmer, A. Pines
    J. Am. Chem. Soc. 2004, 126, 15287-15294
  1. Synthesis of a PNA-encoded cysteine protease inhibitor library
    F. Debaene, L. Mejias, J. L. Harris, N. Winssinger
    Tetrahedron 2004, 60, 8677-8690
  1. Modular Asymmetric Synthesis of Pochonin C
    S. Barluenga, P. Lopez, E. Moulin, N. Winssinger
    Angew. Chem. Int. Ed. 2004, 43, 3467-3470
  1. Applications of laser-polarized 129xe to biomolecular assays
    T. J. Lowery, S. M. Rubin, E. J. Ruiz, M. M. Spence, N. Winssinger, P. G. Schultz, A. Pines, D. E. Wemmer
    Magn. Reson. Imaging 2003, 21, 1235-1239
  1. Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis
    F. Debaene, N. Winssinger
    Org. Lett. 2003, 5, 4445-4447
  1. Novel strategies for the solid phase synthesis of substituted indolines and indoles
    K. C. Nicolaou, A. J. Roecker, R. Hughes, R. van Summeren, J. A. Pfefferkorn, N. Winssinger
    Bioorg. Med. Chem. 2003, 11, 465-476
  1. Profiling protein function with small molecule microarrays
    N. Winssinger, S. Ficarro, P. G. Schultz, J. L. Harris
    Proc. Natl. Acad. Sci. USA 2002, 99, 11139-11144
  1. From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling
    N. Winssinger, J. L. Harris, B. J. Backes, P. G. Schultz
    Angew. Chem. Int. Ed. 2001, 40, 3152-3155
  1. Synthesis and Biological Evaluation of Vancomycin Dimers with Potent Activity against Vancomycin-Resistant Bacteria: Target-Accelerated Combinatorial Synthesis
    K. C. Nicolaou, R. Hughes, S. Y. Cho, N. Winssinger, H. Labischinski, R. Endermann
    Chem. Eur. J. 2001, 7, 3824-3843
  1. Solid- and Solution-Phase Synthesis of Vancomycin and Vancomycin Analogues with Activity against Vancomycin-Resistant Bacteria
    K. C. Nicolaou, S. Y. Cho, R. Hughes, N. Winssinger, C. Smethurst, H. Labischinski, R. Endermann
    Chem. Eur. J. 2001, 7, 3798-3823
  1. A New Photolabile Linker for the Photoactivation of Carboxyl Groups
    K. C. Nicolaou, B. S. Safina, N. Winssinger
    Synlett 2001, 900-903
  1. Epothilones and Sarcodictyins: From Combinatorial Libraries to Designed Analogs
    N. Winssinger, K. C. Nicolaou
    in Anticancer Agents: Frontiers in Cancer Chemotherapy; I. Ojima, G. D. Vite, and K.-H. Altmann (Eds.)ACS Symposium Series, Vol. 796; ACS Press, 2001; Chap. 9; p. 148-170
  1. Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria
    K. C. Nicolaou, R. Hughes, S. Y. Cho, N. Winssinger, C. Smethurst, H. Labischinski, R. Endermann
    Angew. Chem. Int. Ed. 2000, 39, 3823-3828
  1. Total Synthesis of 16-Desmethylepothilone B, Epothilone B10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues
    K. C. Nicolaou, D. Hepworth, N. P. King, M. R. V. Finlay, R. Scarpelli, M. M. A. Pereira, B. Bollbuck, A. Bigot, B. Werschkun, N. Winssinger
    Chem. Eur. J. 2000, 6, 2783-2800
  1. New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin
    K. C. Nicolaou, N. Winssinger, R. Hughes, C. Smethurst, S. Y. Cho
    Angew. Chem. Int. Ed. 2000, 39, 1084-1088
  1. The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century
    K. C. Nicolaou, D. Vourloumis, N. Winssinger, P. S. Baran
    Angew. Chem. Int. Ed. 2000, 39, 44-122
  1. Total Synthesis and Chemical Biology of the Sarcodictyins
    K. C. Nicolaou, J. Pfefferkorn, J. Xu, N. Winssinger, T. Ohshima, S. Kim, S. Hosokawa, D. Vourloumis, F. van Delft, T. Li
    Chem. Pharm. Bull. 1999, 47, 1199-1213
  1. Total Synthesis of Vancomycin—Part 4: Attachment of the Sugar Moieties and Completion of the Synthesis
    K. C. Nicolaou, H. J. Mitchell, N. F. Jain, T. Bando, R. Hughes, N. Winssinger, S. Natarajan, A. E. Koumbis
    Chem. Eur. J. 1999, 5, 2648-2667
  1. Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics
    K. C. Nicolaou, C. N. C. Boddy, S. Bräse, N. Winssinger
    Angew. Chem. Int. Ed. 1999, 38, 2096-2152
  1. Synthesis of the macrocyclic core of sanglifehrin A
    K. C. Nicolaou, T. Ohshima, F. Murphy, S. Barluenga, J. Xu, N. Winssinger
    Chem. Commun. 1999, 809-810
  1. Total Synthesis of Vancomycin
    K. C. Nicolaou, H. J. Mitchell, N. F. Jain, N. Winssinger, R. Hughes, T. Bando
    Angew. Chem. Int. Ed. 1999, 38, 240-244
  1. Polymer-supported selenium reagents for organic synthesis
    K. C. Nicolaou, J. Pastor, S. Barluenga, N. Winssinger
    Chem. Commun. 1998, 1947-1948
  1. Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial Sarcodictyin Libraries
    K. C. Nicolaou, N. Winssinger, D. Vourloumis, T. Ohshima, S. Kim, J. Pfefferkorn, J. Xu, T. Li
    J. Am. Chem. Soc. 1998, 120, 10814-10826
  1. The Art and Science of Organic and Natural Products Synthesis
    K. C. Nicolaou, E. J. Sorensen, N. Winssinger
    J. Chem. Educ. 1998, 75, 1225-1258
  1. Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone
    K. C. Nicolaou, N. Winssinger, J. Pastor, F. Murphy
    Angew. Chem. Int. Ed. 1998, 37, 2534-2537
  1. Solid-Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide
    K. C. Nicolaou, N. Watanabe, J. Li, J. Pastor, N. Winssinger
    Angew. Chem. Int. Ed. 1998, 37, 1559-1561
  1. Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Synthesis of a (dl)-Muscone Library
    K. C. Nicolaou, J. Pastor, N. Winssinger, F. Murphy
    J. Am. Chem. Soc. 1998, 120, 5132-5133
  1. Designed Epothilones: Combinatorial Synthesis, Tubulin Assembly Properties, abd Cytotoxic Action against Taxol-Resistant Tumor Cells
    K. C. Nicolaou, D. Vourloumis, T. Li, J. Pastor, N. Winssinger, Y. He, S. Ninkovic, F. Sarabia, H. Vallberg, F. Roschangar, N. P. King, M. R. V. Finlay, P. Giannakakou, P. Verdier-Pinard, E. Hamel
    Angew. Chem. Int. Ed. Engl. 1997, 36, 2097-2103
  1. Synthesis of epothilones A and B in solid and solution phase
    K. C. Nicolaou, N. Winssinger, J. Pastor, S. Ninkovic, F. Sarabia, Y. He, D. Vourloumis, Z. Yang, T. Li, P. Giannakakou, E. Hamel
    Nature 1997, 387, 268-272
  1. A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE)
    K. C. Nicolaou, N. Winssinger, J. Pastor, F. DeRoose
    J. Am. Chem. Soc. 1997, 119, 449-450
  1. Versatile Method for Parallel Synthesis
    H. V. Meyers, G. J. Dilley, T. L. Durgin, T. S. Powers, N. A. Winssinger, H. Zhu, M. R. Pavia
    Methods Mol. Cell. Biol. 1996, 6, 1-7
  1. Multiple simultaneous synthesis of phenolic libraries
    H. V. Meyers, G. J. Dilley, T. L. Durgin, T. S. Powers, N. A. Winssinger, H. Zhu, M. R. Pavia
    Mol. Divers. 1995, 1, 13-20