- Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
E. E. Watson, F. Russo, D. Moreau, N. Winssinger
Angew. Chem. Int. Ed. 2022, 61, e202203390
A Ru(bpy) 3 photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.
open archive unige:161909