List   Previous   Next  

Publication 28  

  1. Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis
    F. Debaene, N. Winssinger
    Org. Lett. 2003, 5, 4445-4447

A practical and efficient method for PNA synthesis using an azide group to mask the N-terminus is reported. The deprotection was carried out in 5 min, while couplings were complete within 60 min. The near neutral conditions of the phosphine deprotection combined with the base-free coupling using hydroxybenzotriazole-activated monomers make this approach very mild.

DOI: 10.1021/ol0358408 

open archive unige:24519