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Publication 36  

  1. Solution- and Solid-Phase Synthesis of Radicicol (Monorden) and Pochonin C
    S. Barluenga, E. Moulin, P. Lopez, N. Winssinger
    Chem. Eur. J. 2005, 11, 4935-4952

Macrolides with a broad biological activity based on recorcinol-based compounds are described. An expedient and modular synthesis of radicicol (Monorden) and pochonin C is reported. A combination of solid-phase chemistry and polymer-bound reagents was used to assemble both natural products in seven and eight steps, respectively, from the intermediates depicted.

DOI: 10.1002/chem.200500160 

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