4. Synthesis of epothilones A and B in solid and solution phase
   K. C. Nicolaou, N. Winssinger, J. Pastor, S. Ninkovic, F. Sarabia, Y. He, D. Vourloumis, Z. Yang, T. Li, P. Giannakakou, E. Hamel
   Nature 1997, 387, 268-272
   [ Correction: Nature 1997, 390, 100]

Epothilones A and B, two compounds that have been recently isolated from myxobacterium Sorangium cellulosum strain 90, have generated intense interest among chemists, biologists and clinicians owing to the structural complexity, unusual mechanism of interaction with microtubules and anticancer potential of these molecules.

DOI : 10.1038/387268a0 

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