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Publication 75  

  1. Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions
    K. Gorska, J. Beyrath, S. Fournel, G. Guichard, N. Winssinger
    Chem. Commun. 2010, 46, 7742-7744

Oligomerization of receptors induced or stabilized by polyvalent ligands is a fundamental mechanism in cellular recognition and signal transduction. Herein we report a general approach to encode complex peptide macrocycles with peptide nucleic acid (PNA) tags and program their oligomerization through hybridization as exemplified with a ligand binding to oligomeric DR5, a receptor of TRAIL cytokine.


DOI: 10.1039/C0CC02852E 

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