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Publication 8  

  1. Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone
    K. C. Nicolaou, N. Winssinger, J. Pastor, F. Murphy
    Angew. Chem. Int. Ed. 1998, 37, 2534-2537

No heteroatom required! In many solid-phase syntheses, after the release from the polymer support a heteroatom (e.g. O, S, N) remains in the substrate as a residue of a linking protecting group. With polymer-bound tin reagents cleavage and cyclization of the substrate with C-C bond formation (see picture) can now be achieved by intramolecular Stille coupling. S=substrate.

DOI: 10.1002/(SICI)1521-3773(19981002)37:18<2534::AID-ANIE2534>3.0.CO;2-F 

open archive unige:24497