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Publication 89
- Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries
J.-P. Daguer, M. Ciobanu, S. Barluenga, N. Winssinger
Org. Biomol. Chem. 2012, 10, 1502-1505
Dehydrocholic acid was identified as a selective streptavidin binder from a PNA-tagged library. Isothermal calorimetry titration measurements showed this interaction to be entropically driven. Peptides tagged with dehydrocholic acid can be captured on a streptavidin resin and released under thermal conditions.
DOI: 10.1039/c2ob06880j
open archive unige:24671