SPECIAL ISSUES

DMD 2018-2

New Models in Drug Metabolism and Transport

Emerging Models of Drug Metabolism, Transporters, and Toxicity. Aarti Sawant-Basak and R. Scott Obach. DOI

Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity. Albert P. Li, Novera Alam, Kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang. DOI

Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics. Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras. DOI

A Novel In Vitro Experimental System for the Evaluation of Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Cryopreserved Human Hepatocytes). Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz. DOI

Assessment of the Biotransformation of Low-Turnover Drugs in the HµREL Human Hepatocyte Coculture Model. Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler. DOI

Advances in Engineered Human Liver Platforms for Drug Metabolism Studies. Gregory H. Underhill and Salman R. Khetani. DOI

Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions. Shyam Sundhar Bale and Jeffrey T. Borenstein. DOI

Perspective on the Application of Microphysiological Systems to Drug Transporter Studies. Pedro Caetano-Pinto and Simone H. Stahl. DOI

Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk? J. Gerry Kenna and Jack Uetrecht. DOI

Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Piyush Bajaj, Swapan K. Chowdhury, Robert Yucha, Edward J. Kelly and Guangqing Xiao. DOI

Porcine Prediction of Pharmacokinetic Parameters in People: A Pig in a Poke? Huadong Tang and Michael Mayersohn. DOI

Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo. Kazuto Yasuda, Samit Ganguly and Erin G. Schuetz. DOI

Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans. Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki. DOI

Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier. Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuo Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara. DOI

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box. M. Karlgren, I. Simoff, M. Keiser, S. Oswald and P. Artursson. DOI

Mouse Population-Based Approaches to Investigate Adverse Drug Reactions. Merrie Mosedale. DOI