Clinical Pharmacology and Therapeutics 2018

  • Clin Pharmacol Ther. 2018;104:900-915. Disease-associated changes in drug transporters may impact the pharmacokinetics and/or toxicity of drugs: a white paper from the International Transporter Consortium. Evers R, Piquette-Miller M, Polli JW, Russel FGM, Sprowl JA, Tohyama K, Ware JA, de Wildt SN, Xie W, Brouwer KLR; International Transporter Consortium. PubMed
  • Clin Pharmacol Ther. 2018;104:781-784. ITC commentary on Metformin clinical Drug-Drug Interaction study design that enables an efficacy- and safety-based dose adjustment decision. Zamek-Gliszczynski MJ, Chu X, Cook JA, Custodio JM, Galetin A, Giacomini KM, Lee CA, Paine MF, Ray AS, Ware JA, Wittwer MB, Zhang L; International Transporter Consortium. PubMed
  • Clin Pharmacol Ther. 2018;104:803-817. Influence of transporter polymorphisms on drug disposition and response: a perspective from the International Transporter Consortium. Yee SW, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM. PubMed
  • Clin Pharmacol Ther. 2018,104:818-835. Molecular modeling of drug-transporter interactions-an International Transporter Consortium perspective. Schlessinger A, Welch MA, van Vlijmen H, Korzekwa K, Swaan PW, Matsson P. PubMed
  • Clin Pharmacol Ther. 2018;104: 865-889. Advancing predictions of tissue and intracellular drug concentrations using in vitro, imaging and PBPK modeling approaches. Guo Y, Chu X, Parrott NJ, Brouwer KLR, Hsu V, Nagar S, Matsson P, Sharma P, Snoeys J, Sugiyama Y, Tatosian D, Unadkat JD, Huang SM, Galetin A; International Transporter Consortium. PubMed
  • Clin Pharmacol Ther. 2018; 104:916-932. Aug 23. Can BSEP inhibition testing in drug discovery and development reduce liver injury risk? - An International Transporter Consortium perspective. Kenna JG, Taskar KS, Battista C, Bourdet DL, Brouwer KLR, Brouwer KR, Dai D, Funk C, Hafey MJ9 Lai Y, Maher J, Anne Pak Y, Pedersen JM, Polli JW, David Rodrigues A, Watkins PB, Yang K, Yucha RW. PubMed
  • Clin Pharmacol Ther. 2018;104:766-771. The International Transporter Consortium: summarizing advances in the role of transporters in drug development. Giacomini KM, Galetin A, Huang SM. PubMed
  • Clin Pharmacol Ther. 2018;104:890-899-915. Transporters in drug development: 2018 ITC recommendations for transporters of emerging clinical importance. Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y; International Transporter Consortium. PubMed