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Publication 130  

  1. Macrocyclization of Oxetane Building Blocks with Diazocarbonyl Derivatives under Rhodium(II) Catalysis
    Diane Rix, Rafael Ballesteros-Garrido, Walid Zeghida, Céline Besnard, Jérôme Lacour
    Angew. Chem. Int. Ed. 2011, 50, 7308-7311

Highly concentrated: The title reaction proceeds to afford a rare type of 15-membered polyether macrocycle in up to 84 % yield (R1=alkyl, alkoxy, O-allyl, OCH2CH2Ph; R2=alkyl, Ph; R3=H, Me, Et). This nontemplated macrocyclization is performed in a single pot under high concentration and precludes the usual polymerization.

DOI: 10.1002/anie.201102152 

open archive unige:16745