- An Air-stable Cationic Iridium Hydride as a Highly Active and General Catalyst for the Isomerization of Terminal Epoxides
Nicolas Humbert, Devendra J. Vyas, Céline Besnard, Clément Mazet*
Chem. Commun. 2014, 50, 10592-10595
We describe the use of an air-stable iridium hydride catalyst for the isomerization of terminal epoxides into aldehydes with perfect regioselectivity. The system operates at low loadings of catalyst (0.5 mol%), is highly practical, scalable, and tolerates functional groups that would not be compatible with Lewis acids typically used in stoichiometric amounts. Evidence for a rare hydride mechanism are provided.
open archive unige:39470
Editor’s version DOI: 10.1039/C4CC05260A