Reactions developed in the Mazet group are equally methodology-driven and target-oriented. On one hand, the challenges associated with novel reactivity and selectivity often stimulates the interest for a given transformation. On the other hand, our selection of (asymmetric) target reactions is guided by the objective of synthesizing molecules that could serve as versatile building blocks. Hence, accessing structural motifs that are highly prevalent in synthesis but which – paradoxically – lack general preparation methods, provides a strong stimulus to our research program. In this context, we place a particular emphasis on asymmetric catalysis, driven by the devise of new reactivity patterns and unprecedented reaction mechanisms.