48. Palladium-Catalyzed Enantioselective Intermolecular Carboetherification of Dihydrofurans
    Gustavo M. Borrajo Calleja, Vincent Bizet, Clément Mazet*
    J. Am. Chem. Soc. 2016, 138, 4014-4017
    [ Highlighted in: Synfacts 2016, 12, 0591 ]

A novel enantioselective Pd-catalyzed intermolecular carboetherification of dihydrofurans is reported. The in situ generation of chiral bisphosphine monooxide (BPMO) ligands is crucial and a general catalytic system has been identified based on this approach. It provides access to a variety of fused tetrahydrofurobenzofurans in consistently high yield and enantiomeric excess.

archive ouverte unige:82180

DOI de la version éditeur : 10.1021/jacs.6b02158