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Publication 101  

  1. Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates
    A. Novoa, S. Barluenga, C. Serba, N. Winssinger
    Chem. Commun. 2013, 49, 7608-7610

An expedient and simple protocol to access S-linked glycopeptides by Fmoc SPPS using unprotected carbohydrates is reported. The utility of the method was demonstrated with the solid phase synthesis of a MUC1 fragment (20 mer) containing two glycosylation sites that were substituted with S-linked glycans.

DOI: 10.1039/c3cc43458c 

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