List   Previous   Next  

Publication 150  

  1. Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics
    J. Saarbach, P. M. Sabale, N. Winssinger
    Curr. Opin. Chem. Biol. 2019, 52, 112-124

Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability of hybridization complexes (either as duplexes or triplexes), metabolic stability, and ease of chemical modifications. These features have enabled important applications such as antisense agents, gene editing, nucleic acid sensing and as a platform to program the assembly of PNA-tagged molecules. Here, we review recent advances in these areas.

DOI: 10.1016/j.cbpa.2019.06.006 

open archive unige:123664