21. Epothilones and Sarcodictyins: From Combinatorial Libraries to Designed Analogs
    N. Winssinger, K. C. Nicolaou
    in Anticancer Agents: Frontiers in Cancer Chemotherapy; I. Ojima, G. D. Vite, K.-H. Altmann (Eds.)ACS Symposium Series, Vol. 796; ACS Press, 2001; Chap. 9; p. 148-170

The epothilones and sarcodictyins have shown to be potent cytotoxic compounds with a Taxol^TM-like mode of action. The clinical importance of Taxol^TM has stimulated intense research into finding compounds with prospective superior chemotherapeutic properties to Taxol^TM. We have developed enabling synthetic technologies for the construction of combinatorial libraries of these two potentially important chemotherapeutics, which led, in both cases to compounds with superior biological activity.

DOI : 10.1021/bk-2001-0796.ch009 

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