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Publication 22  

  1. A New Photolabile Linker for the Photoactivation of Carboxyl Groups
    K. C. Nicolaou, B. S. Safina, N. Winssinger
    Synlett 2001, 900-903

A new photolabile linker enabling nucleophilic cleavage of a carboxyl functionality upon irradiation with UV light (> 290 nm) was developed. When the photocleavage is carried out in the presence of primary or secondary amines, amides are obtained in high yields and purities, while the intramolecular version of this reaction leads to heterocycles via a cyclorelease mechanism.

DOI: 10.1055/s-2001-14661 

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