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Publication 39  

  1. Concise Synthesis of Pochonin A, an HSP90 Inhibitor
    E. Moulin, S. Barluenga, N. Winssinger
    Org. Lett. 2005, 7, 5637-5639

An expedient synthesis of (-)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.

DOI: 10.1021/ol052263+ 

open archive unige:24507