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Publication 64  

  1. Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights
    S. Barluenga, J.-G. Fontaine, C. Wang, K. Aouadi, R. Chen, K. Beebe, L. Neckers, N. Winssinger
    ChemBioChem 2009, 10, 2753-2759

Potent pochoximes: We generated an extended library of pochoxime inhibitors of heat shock protein 90 and identified a pochoxime that has a cellular efficacy of less than 10 nm. By examining cocrystal structures of pochoximes with human HSP90α, we found that these compounds bind to a different conformation of HSP90 than the closely related radicicol.

DOI: 10.1002/cbic.200900494 

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