nanoDSF

Differential Scanning Fluorimetry for: thermal stability, binding of protein/DNA/RNA in presence of ligands

MST

Microscale Thermophoresis for: binding studies of protein/nucleic acids/ligands

SEC-MALS

Size-exclusion chromatography (SEC) with Multi Angle Light Scattering (MALS) for: protein/nucleic acids/ligand complex size determination

Mass Photometery

Mass Photometery for: absolute mass determination of protein/nucleic acids/ligands

SPR

Surface Plasmon Resonance for: binding studies of protein/nucleic acids/ligands

AlphaScreen

Bead-based luminescent proximity assay for: protein-protein, protein modification detection

Macromolecular crystallography

Macromolecular crystallography for: atomic structure determination

Protein structure prediction & analysis

Analysis of AI predicted protein structures: analysis, mapping of HDX-Mass Spec, Cross-Link Mass Spec data

AI/Structure-guided protein engineering

AI/Structure-guided protein engineering for: design of mutants, design of protein fusions

Molecular dynamics simulations

Molecular dynamics simulations for: sampling of protein/nucleic acid/ligands structure conformations