Anne NIES    SITE

 

  • Front Pharmacol. 2021;12:661480. Effects of a common eight base pairs duplication at the exon 7-intron 7 junction on splicing, expression, and function of OCT1. Römer S, Meyer MJ, Klein K, Schneider LV, Matthaei J, Tzvetkova A, Łapczuk-Romańska J, Gaedcke J, Droździk M, Brockmöller J, Nies AT, Tzvetkov MV. PubMed
  • Pharmaceutics. 2021;13:369. Interaction of Remdesivir with clinically relevant hepatic drug Uptake transporters. Nies AT, König J, Hofmann U, Kölz C, Fromm MF, Schwab M. PubMed
  • Handb Exp Pharmacol. 2021;In press. Genetic and epigenetic regulation of Organic Cation Transporters. Kölz C, Schaeffeler E, Schwab M, Nies AT. PubMed
  • Fundam Clin Pharmacol. 2021;In press. Inhibition of organic cation transporter 3 activity by tyrosine kinase inhibitors. Alim K, Moreau A, Bruyère A, Jouan E, Denizot C, Nies AT, Parmentier Y, Fardel O. PubMed
  • Proc Natl Acad Sci U S A. 2021;118:e2020168118. Targeting OCT3 attenuates doxorubicin-induced cardiac injury. Huang KM, Zavorka Thomas M, Magdy T, Eisenmann ED, Uddin ME, DiGiacomo DF, Pan A, Keiser M, Otter M, Xia SH, Li Y, Jin Y, Fu Q, Gibson AA, Bonilla IM, Carnes CA, Corps KN, Coppola V, Smith SA, Addison D, Nies AT, Bundschuh R, Chen T, Lustberg MB, Wang J, Oswald S, Campbell MJ, Yan PS, Baker SD, Hu S, Burridge PW, Sparreboom A. PubMed
  • Xenobiotica. 2021;51:467-478. Bruyère A, Le Vée M, Jouan E, Molez S, Nies AT, Fardel O. Differential in vitro interactions of the Janus kinase inhibitor ruxolitinib with human SLC drug transporters. PubMed
  • Br J Pharmacol. 2021;178:1459-1474.  Neul C, Hofmann U, Schaeffeler E, Winter S, Klein K, Giacomini KM, Eichelbaum M, Schwab M, Nies AT. Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins. PubMed
  • Front Endocrinol. 2020;11:532. The membrane transporter OAT7 (SLC22A9) is not a susceptibility factor for osteoporosis in europeans. Nies AT, Weiss S, Schaeffeler E, Hannemann A, Völker U, Wallaschofski H, Schwab M. PubMed
  • Anal Chem. 2020;92:11851-11859. Direct Automated MALDI Mass Spectrometry analysis of cellular transporter function: Inhibition of OATP2B1 uptake by 294 drugs. Unger MS, Schumacher L, Enzlein T, Weigt D, Zamek-Gliszczynski MJ, Schwab M, Nies AT, Drewes G, Schulz S, Reinhard FBM, Hopf C. PubMed
  • Mol Pharm. 2020;17:488-498. Clinically relevant OATP2B1 inhibitors in marketed drug space. Unger MS, Mudunuru J, Schwab M, Hopf C, Drewes G, Nies AT, Zamek-Gliszczynski MJ, Reinhard FBM. PubMed
  • Clin Pharmacol Ther. 2020;107:227-237. Sorafenib activity and disposition in liver cancer does not depend on Organic Cation Transporter 1. Chen M, Neul C, Schaeffeler E, Frisch F, Winter S, Schwab M, Koepsell H, Hu S, Laufer S, Baker SD, Sparreboom A, Nies AT. PubMed
  • Toxicol In Vitro. 2019;54:10-22. Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines. Sayyed K, Camillerapp C, Le Vée M, Bruyère A, Nies AT, Abdel-Razzak Z, Fardel O. PubMed
  • Int J Cancer. 2018;143:3181-3193. Characterization of the breast cancer resistance protein (BCRP/ABCG2) in clear cell renal cell carcinoma. Reustle A, Fisel P, Renner O, Büttner F, Winter S, Rausch S, Kruck S, Nies AT, Hennenlotter J, Scharpf M, Fend F, Stenzl A, Bedke J, Schwab M, Schaeffeler E. PubMed
  • Mol Pharm. 2018;15:3557-3572. Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. Dickens D, Rädisch S, Chiduza GN, Giannoudis A, Cross MJ, Malik H, Schaeffeler E, Sison-Young RL, Wilkinson EL, Goldring CE, Schwab M, Pirmohamed M, Nies AT. PubMed
  • Drug Discov Today. 2018;23:1746-1760. The fruit fly Drosophila melanogaster as an innovative preclinical ADME model for solute carrier membrane transporters, with consequences for pharmacology and drug therapy. Wang Y, Moussian B, Schaeffeler E, Schwab M, Nies AT. PubMed
  • Hepatology. 2018;67:1609-1619. Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia. Fujiwara R, Haag M, Schaeffeler E, Nies AT, Zanger UM, Schwab M. PubMed
  • Cancer Res. 2017;77:2102-2111. OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Drenberg CD, Gibson AA, Pounds SB, Shi L, Rhinehart DP, Li L, Hu S, Du G, Nies AT, Schwab M, Pabla N, Blum W, Gruber TA, Baker SD, Sparreboom A. PubMed
  • Expert Opin Drug Metab Toxicol. 2017;13:361-365. The importance of drug transporter characterization to precision medicine. Fisel P, Nies AT, Schaeffeler E, Schwab M. PubMed
  • Trends Pharmacol Sci. 2016;37:904-932. Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors. Neul C, Schaeffeler E, Sparreboom A, Laufer S, Schwab M, Nies AT. PubMed
  • Arch Toxicol. 2016;90:1555-84. Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine. Nies AT, Damme K, Kruck S, Schaeffeler E, Schwab M. PubMed
  • Nat Commun. 2016;7:10880. A phosphotyrosine switch regulates organic cation transporters. Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JHM, Isacoff EY, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N. PubMed
  • Clin Pharmacokinet. 2016;55:507-24. Development of human membrane transporters: Drug disposition and pharmacogenetics. Mooij MG, Nies AT, Knibbe CA, Schaeffeler E, Tibboel D, Schwab M, de Wildt SN. PubMed
  • Pharmacogenomics J. 2016;16:341-51. Variability in hepatic expression of organic anion transporter 7/SLC22A9, a novel pravastatin uptake transporter: impact of genetic and regulatory factors. Emami Riedmaier A1, Burk O, van Eijck BA, Schaeffeler E, Klein K, Fehr S, Biskup S, Müller S, Winter S, Zanger UM, Schwab M, Nies AT. PubMed
  • Pharmacogenomics J. 2016;16:193-201. Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant.Arlanov R, Lang T, Jedlitschky G, Schaeffeler E, Ishikawa T, Schwab M, Nies AT. PubMed
  • Clin Pharmacokinet. 2015;54:709-35. Impact of genetic polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on drug disposition and potential clinical implications: update of the literature. Wolking S, Schaeffeler E, Lerche H, Schwab M, Nies AT. PubMed
  • Adv Cancer Res. 2015;125:217-43. Role of ABC transporters in fluoropyrimidine-based chemotherapy response. Nies AT, Magdy T, Schwab M, Zanger UM. PubMed
  • J Intern Med. 2015;277:235-247. Stratified medicine for the use of antidiabetic medication in treatment of type II diabetes and cancer: where do we go from here? Emami-Riedmaier A, Schaeffeler E, Nies AT, Mörike K, Schwab M. PubMed
  • Drug Metab Dispos. 2014;42:2033-40. Differential expression of drug uptake and efflux transporters in Japanese patients with hepatocellular carcinoma. Namisaki T, Schaeffeler E, Fukui H, Yoshiji H, Nakajima Y, Fritz P, Schwab M, Nies AT. PubMed  
  • Expert Opin Drug Metab Toxicol. 2014;10:395-408. Solute carrier transporter and drug-related nephrotoxicity: the impact of proximal tubule cell models for preclinical research. Fisel P, Renner O, Nies AT, Schwab M, Schaeffeler E. PubMed
  • Clin Cancer Res. 2014;20:985-94. Cellular uptake of imatinib into leukemic cells is independent of human organic cation transporter 1 (OCT1). Nies AT, Schaeffeler E, van der Kuip H, Cascorbi I, Bruhn O, Kneba M, Pott C, Hofmann U, Volk C, Hu S, Baker SD, Sparreboom A, Ruth P, Koepsell H, Schwab M. PubMed
  • Genome Med. 2013;5:1. Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1. Nies AT, Niemi M, Burk O, Winter S, Zanger UM, Stieger B, Schwab M, Schaeffeler E. PubMed
  • Trends Pharmacol Sci. 2013;34:126-35. Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects. Emami Riedmaier A, Fisel P, Nies AT, Schaeffeler E, Schwab M. PubMed
  • Expert Opin Drug Metab Toxicol. 2012;8:1565-77. Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs. Nies AT, Damme K, Schaeffeler E, Schwab M. PubMed
  • Pharmacol Rev. 2012;64:421-49. Organic anion transporters and their implications in pharmacotherapy. Emami Riedmaier A, Nies AT, Schaeffeler E, Schwab M. PubMed
  • Genome Med. 2011;3:82. DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma. Schaeffeler E, Hellerbrand C, Nies AT, Winter S, Kruck S, Hofmann U, van der Kuip H, Zanger UM, Koepsell H, Schwab M. PubMed
  • Expert Rev Clin Pharmacol. 2010;3:707-11. Organic cation transporter pharmacogenomics and drug-drug interaction. Nies AT1, Schwab M. PubMed
  • Drug Metab Rev. 2011;43:499-523. Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics. Damme K, Nies AT, Schaeffeler E, Schwab M. PubMed
  • PLoS One. 2011;6:e22163. Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs). Nies AT, Hofmann U, Resch C, Schaeffeler E, Rius M, Schwab M. PubMed
  • Handb Exp Pharmacol. 2011;201:105-67. Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. Nies AT, Koepsell H, Damme K, Schwab M. PubMed
  • Expert Opin Drug Metab Toxicol. 2008;4:545-68. Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs. Nies AT, Schwab M, Keppler D. PubMed
  • Naunyn Schmiedebergs Arch Pharmacol. 2008;376:449-61. Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Nies AT, Herrmann E, Brom M, Keppler D. PubMed
  • Pflugers Arch. 2007;453:643-59. The apical conjugate efflux pump ABCC2 (MRP2). Nies AT, Keppler D. PubMed
  • J Hepatol. 2003;39:693-702. Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D. PubMed
  • Hepatology. 2003;38:374-84. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D. PubMed
  • Lab Invest. 2003;83:527-38. Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Cui Y, König J, Nies AT, Pfannschmidt M, Hergt M, Franke WW, Alt W, Moll R, Keppler D. PubMed
  • Am J Physiol Gastrointest Liver Physiol. 2003;284:G165-74. A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2). Keitel V, Nies AT, Brom M, Hummel-Eisenbeiss J, Spring H, Keppler D. PubMed

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Last update: October 2021