PHARMACOLOGY

Mary VORE

SITE

J Pharmacol Exp Ther. 2019;371:713-717. Hepatic bile formation: Canalicular osmolarity and paracellular and transcellular water flow. Marinelli RA, Vore M, Javitt NB. PubMed

Curr Med Chem. 2019;26:1155-1184. ABC transporters in extrahepatic tissues: Pharmacological regulation in heart and intestine. Villanueva S, Zhang W, Zecchinati F, Mottino A, Vore M. PubMed

J Pharmacol Exp Ther. 2015;355:272-9. Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice. Deng J, Coy D, Zhang W, Sunkara M, Morris AJ, Wang C, Chaiswing L, St Clair D1, Vore M, Jungsuwadee P. PubMed

Toxicology. 2014;320:46-55. Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity. Arias A, Rigalli JP, Villanueva SS, Ruiz ML, Luquita MG, Perdomo VG, Vore M, Catania VA, Mottino AD. PubMed

Compr Physiol. 2013;3:1721-40. Hormonal regulation of hepatic drug biotransformation and transport systems. Ruiz ML, Mottino AD, Catania VA, Vore M. PubMed

Biochem Pharmacol. 2013;86:401-9. Estrogen receptor-α mediates human multidrug resistance associated protein 3 induction by 17α-ethynylestradiol. Role of activator protein-1. Ruiz ML, Rigalli JP, Arias A, Villanueva SS, Banchio C, Vore M, Mottino AD, Catania VA. PubMed

Drug Metab Dispos. 2013;41:275-80. Induction of hepatic multidrug resistance-associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor. Ruiz ML, Rigalli JP, Arias A, Villanueva S, Banchio C, Vore M, Mottino AD, Catania VA. PubMed

J Biol Chem. 2012;287:24784-94. Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. Zhang Y, Li F, Patterson AD, Wang Y, Krausz KW, Neale G, Thomas S, Nachagari D, Vogel P, Vore M, Gonzalez FJ, Schuetz JD. PubMed

Drug Metab Dispos. 2012;40:1252-8. Effect of glucagon-like peptide 2 on hepatic, renal, and intestinal disposition of 1-chloro-2,4-dinitrobenzene. Villanueva SS, Perdomo VG, Ruiz ML, Rigalli JP, Arias A, Luquita MG, Vore M, Catania VA, Mottino AD. PubMed

Pharmacogenet Genomics. 2012;22:273-84. The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal. Jungsuwadee P, Zhao T, Stolarczyk EI, Paumi CM, Butterfield DA, St Clair DK, Vore M. PubMed

Pharmacogenet Genomics. 2011;21:506-15. Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2). Megaraj V, Zhao T, Paumi CM, Gerk PM, Kim RB, Vore M. PubMed

BMC Genomics. 2011;12:95. Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. Athippozhy A, Huang L, Wooton-Kee CR, Zhao T, Jungsuwadee P, Stromberg AJ, Vore M. PubMed

Hepatology. 2010;52:1465-76. Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C. Boaglio AC, Zucchetti AE, Sánchez Pozzi EJ, Pellegrino JM, Ochoa JE, Mottino AD, Vore M, Crocenzi FA, Roma MG. PubMed

J Pharmacol Exp Ther. 2010;335:332-41. Induction of intestinal multidrug resistance-associated protein 2 by glucagon-like Peptide 2 in the rat. Villanueva SS, Arias A, Ruiz ML, Rigalli JP, Pellegrino JM, Vore M, Catania VA, Mottino AD. PubMed

Drug Metab Dispos. 2010;38:1723-30. Hepatobiliary disposition of 3alpha,6alpha-7alpha,12alpha-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters. Megaraj V, Iida T, Jungsuwadee P, Hofmann AF, Vore M. PubMed

Am J Physiol Gastrointest Liver Physiol. 2010;299:G228-35. ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats. Coy DJ, Wooton-Kee CR, Yan B, Sabeva N, Su K, Graf G, Vore M. PubMed

Mol Pharmacol. 2010;77:237-46. The 5'-untranslated region of multidrug resistance associated protein 2 (MRP2; ABCC2) regulates downstream open reading frame expression through translational regulation. Zhang Y, Zhao T, Li W, Vore M. PubMed

Drug Metab Dispos. 2009;37:1277-85. Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens. Arias A, Villanueva SS, Ruiz ML, Luquita MG, Veggi LM, Pellegrino JM, Vore M, Catania VA, Mottino AD. PubMed

Mol Pharmacol. 2009;75:1117-26. Mrp1 localization and function in cardiac mitochondria after doxorubicin. Jungsuwadee P, Nithipongvanitch R, Chen Y, Oberley TD, Butterfield DA, St Clair DK, Vore M. PubMed

Hepatology. 2008;48:1885-95. Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat. Crocenzi FA, Sánchez Pozzi EJ, Ruiz ML, Zucchetti AE, Roma MG, Mottino AD, Vore M. PubMed

Mol Pharmacol. 2008;73:613-5. Progesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression. Vore M, Leggas M. PubMed

Am J Physiol Gastrointest Liver Physiol. 2007;293:G391-402. Disruption of function and localization of tight junctional structures and Mrp2 in sustained estradiol-17beta-D-glucuronide-induced cholestasis. Mottino AD, Hoffman T, Crocenzi FA, Sánchez Pozzi EJ, Roma MG, Vore M. PubMed

Mol Cancer Ther. 2006;5:2851-60. Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 mice. Jungsuwadee P, Cole MP, Sultana R, Joshi G, Tangpong J, Butterfield DA, St Clair DK, Vore M. PubMed

J Pharmacol Exp Ther. 2007;320:893-9. Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate. Gerk PM, Li W, Megaraj V, Vore M. PubMed

Mol Pharmacol. 2007;71:377-83. Translational regulation of rat multidrug resistance-associated protein 2 expression is mediated by upstream open reading frames in the 5' untranslated region. Zhang Y, Li W, Vore M. PubMed

Drug Metab Dispos. 2006;34:1030-4. Ethynylestradiol increases expression and activity of rat liver MRP3. Ruiz ML, Villanueva SS, Luquita MG, Vore M, Mottino AD, Catania VA. PubMed

J Hepatol. 2006;44:232-3. Canalicular membrane localization of hepatocyte aquaporin-8 is preserved in estradiol-17beta-D-glucuronide-induced cholestasis. Mottino AD, Carreras FI, Gradilone SA, Marinelli RA, Vore M. PubMed

Mol Pharmacol. 2005;68:701-10. The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2). Jones BR, Li W, Cao J, Hoffman TA, Gerk PM, Vore M. PubMed

Mol Pharmacol. 2005;68:218-25. Hormonal regulation of hepatic organic anion transporting polypeptides. Wood M, Ananthanarayanan M, Jones B, Wooton-Kee R, Hoffman T, Suchy FJ, Vore M. PubMed

Biochem Pharmacol. 2005;69:531-9. Mechanisms involved in spironolactone-induced choleresis in the rat. Role of multidrug resistance-associated protein 2. Ruiz ML, Villanueva SS, Luquita MG, Sánchez-Pozzi EJ, Crocenzi FA, Pellegrino JM, Ochoa JE, Vore M, Mottino AD, Catania VA. PubMed

Am J Physiol Gastrointest Liver Physiol. 2005;288:G327-36. Role of microtubules in estradiol-17beta-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity. Mottino AD, Crocenzi FA, Pozzi EJ, Veggi LM, Roma MG, Vore M. PubMed

Drug Metab Dispos. 2004;32:1139-45. Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide. Gerk PM, Li W, Vore M. PubMed

Endocrinology. 2004;145:1739-49. Estradiol represses prolactin-induced expression of Na+/taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a. Cao J, Wood M, Liu Y, Hoffman T, Hyde J, Park-Sarge OK, Vore M. PubMed

J Pharmacol Exp Ther. 2003;307:306-13. Biliary secretion of glutathione in estradiol 17beta-D-glucuronide-induced cholestasis. Mottino AD, Veggi LM, Wood M, Román JM, Vore M. PubMed