17 mars 2022: Dr Petter Brodin
CMU - AUDITOIRE ALEX-F. MÜLLER (A250)
Attendance in person for UNIGE/HUG members only
Présentiel réservé uniquement aux membres UNIGE/HUG
Apéritif à l'issue de la présentation.
dR Petter BRODIN
Department of Inflammation and Immunology, Imperial College London
& Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden
«Human systems immunology to understand immune development and variation»
In this lecture, Dr Brodin will discuss recent technological advances pertaining to the assessment of human immune systems at the global level to assess immune regulation and function. Dr Brodin will describe the efforts by his team to unravel the principles of immune system variation, the underlying factors that drive this variation and in particular the developmental trajectories that shape it.
Petter Brodin is Garfield Weston Chair and Professor of pediatric immunology at Imperial College London and professor of Pediatric immunology at Karolinska Institutet in Stockholm, Sweden. The Brodin lab (https://brodinlab.com/) develops and applies novel experimental and computational methods to describe human immune system variation with a particular interest in the immune systems of children, its development early in life, and its role in health and disease during childhood.
After completing a MD/PhD program at the Karolinska Institute, Brodin joined the Mark M Davis’s laboratory at HHMI, Stanford University School of Medicine as a postdoctoral fellow, investigating the contribution of heritable and non-heritable sources of variation in immune systems of twins (Brodin et al, Cell, 2015). Following this, Brodin returned to Sweden to establish a national facility for immunomonitoring at the Swedish infrastructure hub, Science for Life Laboratory. He also established his own research program applying systems-immunology methods to the study of immune system development early in life. The Brodin lab established a birth cohort and showed differences in early life adaptation between preterm and term infants (Olin et al, Cell, 2018), the global repertoire of maternal antiviral antibodies (Pou et al, Nat. Med, 2019) as well as the imprinting effect of select colonizing microbes such as bifidobacterial early in life (Henrick et al, Cell, 2021). The Brodin lab has also applied its technologies for systems-level immune system analysis during the COVID-19 pandemic to understand COVID-19 in children(Brodin, P, Immunity 2022), the immunology of MIS-C (Consiglio et al, Cell, 2020) and severe COVID-19 (Rodriguez et al, Cell Reports Med, 2020) and are active members of the global COVID-Human Genetic Effort (https://www.covidhge.com/).17 mars 2022