The biology of metabolism in health and disease

The Coppari's laboratory has the following main aims:

  • Identifying neuron-types and molecules underlying normal metabolic homeostasis;
  •  Identifying neuron-types and molecules protecting against diet-induced metabolic imbalance;
  •  Identifying neuron-types and molecules permitting life without insulin;
  • Exploiting effect of dietary interventions to unveil cancer vulnerabilities.


The Coppari's laboratory possesses the following  expertise:

  • Generation of genetically-engineered mice bearing neuron-type-restricted mutations;
  •  Metabolic assessments, including glucose/insulin clamp in unrestrained and awake rodents;
  • Dietary interventions affecting cancer biology in rodents.