Job offers
Two-semesters internship for Master students in Biochemistry or Biology
Deciphering the implication of NPC-Vacuolins interaction during M. marinum infection
Context: Infection by M. tuberculosis and M. marinum (a close-relative and opportunistic pathogen) induces accumulation of neutral lipids and sterols in the MCV ( Mycobacterium- containing vacuole) , a phenotype reminiscent of endolysosomal lipid accumulation resulting from mutations in the human Niemann-Pick type C cholesterol transporter (NPC). Mammalian flotillins, protein organizers of membrane sterol-rich microdomains, seems to interact with NPC and this functional interaction might be required for some bacterial infection.
We propose to study flotillins and NPC interaction and role in M. marinum infection using D. discoideum, a 3R phagocyte model, as well as macrophage-like BV-2 cells. We hypothesize that vacuolins, D. discoideum homologues of the flotillins, cooperate with NPCs to generate the sterol-rich microdomains necessary for the mycobacteria-damaging activity and possibly nutrition. We thus aim at investigating the role of NPC in D. discoideum and mammalian BV-2 cells during infection by M. marinum.
Bosmani C, Perret A, Leuba F, Guého A, Hanna N, Soldati T. (2021) Disruption of vacuolin microdomains in the host Dictyostelium discoideum increases resistance to Mycobacterium marinum-induced membrane damage and infection. Preprint: bioRxiv 468763; https://doi.org/10.1101/2021.11.16.468763
The candidate should send CV, transcripts of BSc studies and Motivation Letter to:
Two-semesters internship for Master students in Biochemistry or Biology
Functional characterization of the E3-ubiquitin ligase TrafE in nuclear envelope remodeling
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We are looking for a motivated student willing to study the molecular function of the E3-ubiquitin ligase TrafE in nuclear envelope remodeling. We recently showed that TrafE regulates autophagy- and ESCRT-mediated endolysosomal damage repair and restriction of M. marinum intracellular growth (Raykov et al., (2023) eLife). TrafE transient recruitment to nuclear membranes has also been observed during karyokinesis, however its role in this process remains to be addressed. |
The candidate should send CV, transcripts of BSc studies and Motivation Letter to:
The group welcomes applications from excellent, very motivated collaborators.
We welcome national and international candidates who register with the MSc programs in Biochemistry, Biology, or Chemical Biology, and want to perform a wet-lab internship in our field of research.
We are also interested in outstanding postdoctoral candidates with expertise in various fields of cell biology, biochemistry and genetics, with an emphasis on cellular microbiology, bacteriology and host-pathogen interactions.
It is expected that prospective postdoc candidates will apply for highly selective and prestigious fellowships such as awarded by EMBO, Marie Curie and Human Frontier Science Program.
Candidates interested in any of these positions, please email a complete CV (with DOB, nationality, publication list, grades, etc.), a statement of past achievements and future research interests, and the name and contact details of at least two potential referees to Thierry Soldati ().
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