Pushing and pulling nucleosomes to control transcription initiation

Chromatin remodelers are protein machines that move or eject nucleosomes from the chromatin template to regulate gene expression. Kubik et al. show how two distinct classes of remodelers, which they call « pushers » and « pullers », interact genome-wide at promoter regions to determine both the frequency of gene transcription and the precise site of initiation.


6 Aug 2019

News 2019