A scaffold at the center of our cellular skeleton

All animal cells have an organelle called a centrosome, which is essential to the organization of their cell skeleton. The centrosome plays fundamental roles, especially during cell division, where it allows equal sharing of genetic information between two daughter cells. When the cells stop dividing, the centrioles, cylindrical structures composed of microtubules at the base of the centrosome, migrate to the plasma membrane and allow the formation of primary and mobile cilia, which are used respectively for the transfer of information and the genesis of movement. While performing these crucial biological functions, centrioles are therefore subjected to many physical forces, which they must resist. The group of Paul Guichard and Virginie Hamel has discovered an internal structure at the center of these nano-cylinders, a real cellular scaffolding that maintains the physical integrity of this organelle.Their study will provide a better understanding of the functions of the centriole and the pathologies associated with its dysfunction.

The article was published in Science Advances on February 20, 2020.

Press release



20 Feb 2020

News 2020