Research Groups

Thierry Soldati Group

Research

The major aim of the Soldati group is to understand the cooperation of signalling, cytoskeleton and membrane trafficking in phagocytosis and its relevance to the cell-autonomous immunity against pathogenic bacteria. To this end, we use the genetically and biochemically tractable Dictyostelium discoideum as a model organism. This amoeba is a professional phagocyte very similar in morphology and behaviour to mammalian phagocytes of the innate immune system, but which is ethically un-concerning, allowing significant progress to further the 3Rs cause (Dunn et al, 2018).

  

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