21 mai 2026: Pr David Menon
12H30
CMU - Auditoire Müller
suivi d'un apéritif
Hôte: Pr Jean-Charles SANCHEZ
Centre facultaire d’investigation translationnelle en biomarqueurs (CITB)
Département de médecine, Faculté de médecine UNIGE
Pr David Menon
Director of Research, Department of Medicine, University of Cambridge
"What the patient brings to the injury: Understanding the role of host factors in traumatic brain injury"
Conventionally, traumatic brain injury (TBI), and trauma in general, have been thought to be conditions where disease course and outcome are dominantly driven by the severity of the insult. This has resulted in efforts to more precisely characterise the severity of injury, so as to deliver more targeted care – and there has been substantial progress in this this context. However, there is accumulating evidence that age (both chronological and biological), sex, and prior illness and their therapies have an enormous impact on disease course and outcome. These findings have been now supplemented by a more fundamental understanding of the biological variations in host response that underpin these effects.
This lecture will summarise the evidence for such variations and explore how such knowledge could lead to precision medicine approaches to treating patients with TBI.
Biography
David Menon is Director of Research in the Department of Medicine, Principal Investigator in the Wolfson Brain Imaging Centre, and Principal Investigator in the van Geest Centre for Brain Repair, at the University of Cambridge. Following two terms as a Senior Investigator in the National Institute for Health and Care Research (NIHR), he was appointed emeritus NIHR Senior Investigator in 2019. He is a Founding Fellow of the Academy of Medical Sciences, and a Professorial Life Fellow in the Medical Sciences at Queens’ College, Cambridge. His academic and clinical achievements led to appointment as Commander of the Order of the British Empire (CBE) in June 2024.
He founded and was the first Director of the Neurosciences Critical Care Unit (NCCU) at Addenbrooke’s Hospital, Cambridge, where he established the first recognised training programme for specialist neurocritical care in the UK. Protocols developed in the Addenbrooke’s NCCU have been shown to improve clinical outcome in severe head injury and rationalise the management of acute intracranial haemorrhage.
He jointly leads the EU-funded €30 million CENTER-TBI Consortium (https://www.center-tbi.eu/), the International Initiative on TBI Research (InTBIR; https://intbir.incf.org/), and the €12 million multi-funder UK national Traumatic Brain Injury (TBI) Research Platform (TBI-REPORTER; https://tbi-reporter.uk/). He jointly led the Lancet Neurology Commissions on TBI in 2017 (https://www.thelancet.com/commissions/traumatic-brain-injury) and 2022 (https://www.thelancet.com/commissions/traumatic-brain-injury-progress), and was Executive Editor of the UK All Party Parliamentary Group Report on Acquired Brain Injury (2019: https://ukabif.org.uk/resource/resmgr/campaigns/appg-abi_report_time-for-cha.pdf).
He has been applicant or co-applicant on awarded grants totaling over €50 million. He has over 650 peer-reviewed publications, with a ‘h’ index of 149 (Google Scholar), and has been continuously rated as a Highly Cited Researcher by Clarivate since 2021. The Acute Brain Injury Program at Cambridge, which he founded, has supported over 60 PhD studentships, and nurtured several senior investigators across clinical and basic neuroscience