A review on the modulation of calcium signaling by S-acylation
Calcium orchestrates vital cellular functions from embryonic development to adulthood, controlling processes such as neurotransmission and gene transcription. S-acylation, a lipid modification, is emerging as a key regulator of calcium handling proteins, altering their conformation and interactions. Perturbations in S-acylation disrupt calcium signalling and are implicated in diseases such as heart disease and cancer.
Interested to learn more?
To find out what is known and unknown about S-acylation's role in organelle and plasma membrane calcium transport proteins and its therapeutic potential for diseases rooted in calcium flux dysregulation, download the review from the laboratory of Prof. Nicolas Demaurex published in Biochemical Society Transactions.