Sélection actuelle :25 groupes de recherche
We are a chemical biology group and our research goal is to discover novel signaling and metabolic pathways by using the strategy of forward chemical genetics. We are particularly interested in enzymes involved in cancer and autoimmune diseases. To achieve our goals, we apply a broad repertoire of different technologies ranging from synthetic chemistry to cell biology and mass spectrometry-based proteomics and metabolomics.
Analytical Chemistry, Electrochemistry, Electrochemical Sensors, Optical Detection Principles, Ion Optodes, Exhaustive Sensors, Photoelectric Conversion, Light Activated Extraction, Nanosphere Reagents, Materials Characterization, Polymers and Polymer Modifications, Environmental Analysis, Biomedical Analysis.
The research of the group focuses on fundamental physical and analytical chemistry of colloids, surfaces, and polymers. Applications of these concepts are pursued in industrial process control and environmental chemistry.
Chemistry, spectroscopy and applications of surfaces, interfaces and chiral nanomaterials: Development and application of spectroscopic techniques to probe solid-liquid interfaces, preparation and applications of chiral nanomaterials, enantiodifferentiation, vibrational optical activity, self-assembly of plasmonic nanomaterials.
We are mainly interested in synthesizing topologically complex molecules, using the hydrophobic effect as a driving force. Molecules with complex topologies are entangled macrocycles composed of one or many components, named knots and links, respectively. The formation of knots and links represent an original, but efficient, way to control the three–dimensional shape of molecules, making these structures ideal candidates for a variety of biological applications, such as sequence- and structure-specific binding to proteins and DNA. However, they remain extremely difficult to produce using the current methods of chemistry, and their potential applications constitute an entirely unexplored field.
We want to understand in physical and molecular terms how cells talk to each other during development. This means our research is highly interdisciplinary: physics, cell biology, molecular biology, biochemistry, genetics... Indeed some of us in the lab are biologists, other physicists, chemists, engineers.
We are interested in the signaling events that control tissue growth: how is the shape and final size of a tissue achieved during embryogenesis?
We focus on two types of proliferation modes: growth control by morphogen gradients and asymmetric cell division in stem cells. We do this using two model systems: Drosophila and Zebrafish.
We study membrane dynamics and endosome morphogenesis, using biochemical assays that reconstitute membrane transport steps in vitro, and in vivo studies and genetic manipulations using tissue culture-cells. These studies are combined with high throughput systems-biology approaches and high content screens to obtain a broader overview of the collective behavior of membrane components.
Spectroscopie laser cw, spectroscopie Raman et luminescence, et chimie du solide dans les fluorures (matériaux optiques potentiels) et hydrures (stockage d’hydrogène); caractérisation des propriétés structurales et dynamiques des échantillons par combinaison des techniques structurales et spectroscopiques, et optimisation des stratégies de synthèse en vue d’échantillons avec des propriétés améliorées; applications de la spectroscopie Raman : échantillons biochimiques, équilibres conformationnels.
Photophysical and photochemical properties of transition metal compounds are increasingly being made use of in advanced technological applications. Therefore, it is of more than just academic interest to fully understand the fundamental photophysical and photochemical processes, as for instance laser-induced luminescence, intersystem crossing, internal conversion, excitation energy transfer and light-induced electron transfer, and the parameters which govern their rates and quantum efficiencies.Our research interests are focussed on establishing relationships between structural, electronic as well as energetic parameters, and the dynamics of elementary radiationless processes at a molecular level. Spin-crossover compounds and three-dimensional metal-tris-oxalate networks serve as model systems for their investigation. The main experimental tool is optical spectroscopy in condensed media. This includes polarised single crystal absorption and luminescence techniques as well as time-resolved methods and advanced high-resolution laser spectroscopy at cryogenic temperatures.
Analytical chemistry and mass spectrometry of low molecular weight compounds (pharmaceuticals) and macromolcules (peptides, proteins). Mass spectrometry imaging, Ionization, High resolution MS and data independent acquisition, ion mobility mass spectrometry, coupling MS with separation sciences, data analysis, MS libraries, bioanalysis, metabolism, metabolomics, lipidomics, proteomics, ultra-fast quantitative analysis.
Methodology and signal processing in Nuclear Magnetic Resonance; elucidation of structures of natural products
We study the molecular mechanisms of membrane traffic, especially clathrin-mediated endocytosis. We aim to understand the assembly, function and regulation of the complex molecular machineries that drive the formation of endocytic vesicles. Our main experimental organism is budding yeast. We use a combination of quantitative live-cell imaging, electron microscopy, genetics, biochemistry and structural biology.
We study the formation of spatial and temporal structures in individual biological cells and cells assemblies. The focus of our work is on theoretical descriptions of cytoskeletal dynamics. The cytoskeleton is a network of filamentous proteins, which is kept permanently out of thermodynamic equilibrium. It enables cells to divide, determines their shape and plays an important role in cell locomotion. In our descriptions, we rely heavily on concepts from non-linear dynamics and from non-equilibrium statistical mechanics.
Synthetic organic chemistry, chirality and molecular recognition: Organometallic reactivity and asymmetric transformations; Synthetic, physical and biological applications of highly stable (chiral) carbenium ions; NMR enantiodifferentiation of chiral substances; Hexacoordinated phosphorus chemistry
Organic Synthesis, Supramolecular Chemistry, Bioorganic Chemistry, Functional Systems, Unorthodox Interactions
Synthetic chemistry, asymmetric catalysis, reaction mechanism, characterization of reactive intermediates
Supramolecular chemistry of f-elements.
Synthesis of luminescent and magnetically active polymetallic materials. Thermodynamics of self-assembly. Molecular near-infrared to visible upconversion using linear optics. Thermotropic luminescent liquid crystals.
Biologie cellulaire et moléculaire; mécanismes de biogenèse des membranes et du trafic membranaire; biochimie et génétique des membranes et du trafic membranaire; triage des protéines via la route de sécrétion; fonctions intracellulaires des sphingolipides et stérols.
My research group focuses on understanding how mechanics of lipid membranes can influence the life of cells. The enveloppe of living cells is made of lipid bilayers which impermeability and deformability ensure changes in cell shape while keeping its specific content. We are interested in understanding how membrane mechanical properties can constraint several cell processes at the molecular, cellular and multi-cellular scales. In particular, we focused on how membrane tension and rigidity influence intracellular membrane traffic (in particular endocytosis and Golgi trafficking) and cell division (in particular cytokinesis). We recently started to be interested in multi-cellular systems, in particular epithelia, where membrane tension is proposed to play a role in cell reorganization during organ morphogenesis.
The major aim of my group is to understand the integration of signalling, cytoskeleton and membrane trafficking in phagocytosis and its relevance to host-pathogen interactions. To this end, we use the social amoeba Dictyostelium as a model organism as it is a is genetically and biochemically tractable professional phagocyte very similar to phagocytes of the innate immune system in morphology and behaviour.
We study the fundamental mechanism of lipid self-assembly. The assembled lipid nanostructures are tested for use in applications in the field of biophysics, electrochemistry, materials science and biomedical engineering.
Our research interest involves synthesis, characterization and application of lamellar inorganic materials including layered double hydroxides, titanates and graphite oxide. We particularly focus on aggregation of such nanoparticles in dispersions and their delamination into unilamellar nanosheets in the presence of polyelectrolytes or ionic liquids. We are also interested in applications of these systems in environmental processes, catalysis or as delivery agents.
Ultrafast photochemistry: development and applications of optical spectroscopic methods, investigations of ultrafast photoinduced molecular processes in condensed phase and at liquid interfaces.
Chimie théorique : orbital-free embedding, la fonctionnelle de l’énergie cinétique, description des interactions faibles par la théorie de la fonctionnelle de la densité (DFT); chimie quantique appliquée : physisorption sur les oxydes métalliques et surfaces graphitiques, les molécules sondes dans les zéolites, les réactions enzymatiques, les effets de solvatation, les molécules encapsulées, les complexes supramoléculaires.