Detailed program
The workshop schedule pdf can be downloaded from the link below.
It is subject to change and if you find errors please inform
Times, presenting authors and titles are shown. For abstracts, author lists and affiliations, please consult the printed program available at the meeting.
Sunday June 12th
17:00 Registration available
19:00 Cocktail reception
Monday June 13th
08:30 Registration available
09:00 Welcome and Introduction
Moniek de Maat
Session 1 - Structure biomechanics and polymerization
Chairperson: Moniek de Maat
09:15 State of the Art 1 - John Weisel, University of Pennsylvania
Oral communications
09:45 Ranjini Ramanujam - Fracture mechanics of human blood clots: fibrinogen concentration is a critical determinant of clot toughness
10:05 Valeri Barsegov - Biomechanics, thermodynamics, and mechanisms of rupture of fibrin Clots
10:25 Rustem Litvinov - Contraction of blood clots and thrombosis
10:45 Coffee Break
Session 2 – Fibrinolysis
Chairperson: Robert Ariëns
11:15 State of the Art 2 - Alisa Wolberg, University of North Carolina
Oral communications
11:45 Rebecca Risman - Effects of clot contraction on clot degradation: a mathematical and experimental approach
12:05 Lauren Schmitt - Plasma fibrin clot proteome and FXIII cross-linking analysis reveals differences between fibrinolytic extremes.
12:25 Andrew Gosselin - Hyperfibrinolysis drives instabilities in trauma induced coagulopathy
12:45 Lunch
13:45 Poster session and sponsor booths
14:45 Historical Lecture - Denis Galanakis, Stony Brook University
15:15 Break
Session 3 - Fibrin clot properties I
Chairperson: John Weisel
15:45 State of the Art 3 - Robert Ariëns, University of Leeds
Oral communications
16:15 François Caton - Fibrinogen aggregates dramatically alter fibrin ultrastructure
16:35 Martin Guthold - Automated fiber diameter and porosity measurements of plasma clots in scanning electron microscopy images
16:55 Rita Marchi - Software development to quantify fibrin clot images by laser scanning confocal microscopy (LSCM)
17:15 Poster session and sponsor booths
19:30 Dinner
Tuesday June 14th
08:30 Registration available
Session 4 - Factor XIII
Chairperson: Helen Philippou
09:15 State of the Art 4 - Verena Schroeder, University of Bern
Oral communications
09:45 Cédric Duval - Increased venous thromboembolism in a new mouse model of impaired fibrin α-chain crosslinking
10:05 Muriel Maurer - Exploring contact sites between activated factor XIII and fibrinogen αC (233- 425)
10:25 László Muszbek - Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles
10:45 Break
Session 5 - Fibrin(ogen)-cell interactions I
Chairperson: Matthew Flick
11:15 State of the Art 5 - Leonid Medved, University of Maryland
Oral communications
11:45 Kirby Lattwein - Ultrasound-activated microbubbles for the treatment of fibrin-based biofilms
12:05 Filomena Carvalho - Studying the molecular interactions of fibrinogen with erythrocytes in Carotid Artery Disease
12:25 Lunch
13:45 Poster session and sponsor booths
15:15 Break
Session 6 - Fibrinogen variants
Chairperson: Richard Fish
15:45 State of the Art 6 - Judith de Vries, Erasmus University Medical Center
Oral communications
16:15 Dre’Von Dobson - Identifying genes that regulate fibrinogen expression
16:35 Julie Hahn - DNA methylation analysis identifies novel genetic loci associated with circulating fibrinogen levels in blood
17:30 Transfer to Vevey
18:15 Boat Cruise
Wednesday June 15th
Session 7 - Fibrinogen disorders
Chairperson: Marlien Pieters
09:15 State of the Art 7 - Marguerite Neerman-Arbez, University of Geneva
09:45 State of the Art 8 - Alessandro Casini, Geneva University Hospitals
Oral communication
10:15 Richard Fish - A zebrafish model of dysfibrinogenemia caused by hotspot mutations in the human fibrinogen gamma chain
10:35 Break
Session 8 - Clinical Management
Chairperson: Anetta Undas
11:15 Sponsored Lecture - Asoke Roy, Basingstoke and North Hampshire Hospital
Oral communications
11:45 Alessandro Casini - Outcomes of pregnancy, delivery and post-partum in women with hereditary fibrinogen disorders: the FibrinoGEST study
12:05 Francesca Casalino - Fibrinogen replacement in hereditary dysfibrinogenemia: how much is enough?
12:25 Kirk Hansen - Characterizing plasma fibrin in trauma patients using advanced proteomic approaches
12:45 Lunch
13:45 Poster session and sponsor booths
15:15 Break
Session 9 - Inflammation and Disease
Chairperson: Alisa Wolberg
15:45 State of the Art 9 - Matthew Flick, University of North Carolina
Oral communications
16:15 Marlien Pieters - Serum lipids, apolipoproteins and Lp(a) associate cross-sectionally with plasma clot properties in Africans – epidemiological evidence
16:35 Miriam Rafailovich - Molecular basis for surface initiated non-thrombogenic clot formation following viral infection
16:55 Marlien Pieters - Association of the metabolic syndrome with changes in fibrinogen concentration and fibrin clot properties over a 10-year period
17:15 Poster session and sponsor booths
19:30 Conference Dinner
Thursday June 16th
Session 10 - Fibrin clot properties II
Chairperson: Martin Guthold
Oral communications
09:30 Lauren Poole - Dysregulated fibrinogen γ-chain cross-linking in FibγΔ5 mice drives acute liver injury after acetaminophen overdose
09:50 Helen McPherson - Inclusion of fibrin with truncations in the αC-region dysregulates clot structure: implications for dysfibrinogenaemia
10:10 Timea Feller - Fibrin fibre resistance to rupture is affected by both α- and γ-chain crosslinks mediated by FXIIIa
10:30 Break
Session 11-12 - Tissue engineering / Fibrinogen and COVID-19
Chairperson: Alessandro Casini
Oral communications
11:15 Stephani Stamboroski - Interaction of cells involved in wound healing with self-assembled fibrinogen nanofibers
11:35 Martin Guthold - Mechanical properties of electrospun, blended fibrinogen: PCL nanofibers
11:55 Judith de Vries - Increased percentage of extended Aα chain fibrinogen (αE) in COVID-19 patients
12:15 Zsuzsa Bagoly - Low factor XIII levels and hyperfibrinolysis in pregnancies with COVID-19
12:35 Closing remarks
12:45 Lunch boxes available