The Pathology Department conducts research into anatomical and clinical correlations in human pathology, and in the fields of cell biology, general immunology and immunopathology. 

Concerning cell biology, several teams study:

  • growth factors and the oncogenes involved in the differentiation and functioning of the lymphohematopoietic system
  • the functional role of certain parts of the cytoskeletal apparatus, in particular actin and intermediary filaments, and how they change in the course of the arterial pathology of scar-tissue formation and the development of epithelial tumours and conjunctive tissue
  • the structure and function of the cell membrane

Research in immunology focusses on:

  • Functional specialisation of T lymphocyte subsets under experimental and pathological conditions
  • Synthesis and function of cytokines secreted by cells of the immune system under experimental and pathological conditions
  • Regulation and function of antigen presentation under experimental and pathological conditions

Research in pathology focusses on:

  • Cellular interactions promoting the development of spontaneous and provoked autoimmunity
  • Role of antibodies and immune complexes in triggering vascular lesions
  • Role of immune responses in pathological manifestations associated with infectious disease
  • Intra- and inter-cellular communication leading to the development of cardiovascular disease

Research Groups


Department of Clinical Pathology, Hospital Department of Medical Genetics, of Laboratory and Pathology

Affiliated Clinical Groups

  • Cem Gabay (Department of Medicine)
    Mechanisms of articular inflammation and joint damage in arthritis
  • Wolf-Henning Boehncke (Department of Medicine)
    Mechanisms of the pathologies of the cutaneous inflammation
  • Patrice Lalive (Department of Clinical Neurosciences)
    Neuroimmunology, Experimental autoimmune encephalitis, Multiple sclerosis
  • Nicolas Mach (Department of Medecine)
    Translational Cancer Research
  • Thomas Matthes (Department of Medecine)
    Cellular and Molecular Analysis Tools for Lymphoma and Leukemia Diagnosis

Honorary Professors

  • Dominique Belin - Honorary Professor
    The orphan genes of bacteriophage T4, a biological dark matter
  • Beat Imhof - Honorary Professor
    Adhesion molecules and the process of cell migration
  • Karl-Heinz Krause
    Reactive oxygen species (ROS) and Embryonic stem cells
  • Francesco Negro - Honorary Professor
    Clinical studies and treatment of hepatitis C and B
  • Walter Reith - Honorary Professor Regulation of antigen presentation and antigen presenting cells
  • Claire-Anne Siegrist (Département de pédiatrie, gynécologie et obstétrique)
    Centre de vaccinologie et d'immunologie néonatale