Patrick Meraldi


Publications of the Meraldi group

#equal contribution, §corresponding authorship



Devashish D, Harry D and Meraldi P Mild replication stress causes premature centriole dis-engagement via a sub-critical Plk1 activity under the control of ATR-Chk1 bioRxiv, 2022

#Castrogiovanni C, #Inchingolo AV, Harrison JU, Dudka D, Sen O, Burroughs NJ, §McAinsh AD and §Meraldi P Evidence for a HURP/EB free miced-nucleotide zone in kinetochore-microtubules, Nat Commun, 2022, 13, 4704 doi: 10.1038/s41467-022-32421-x.

§Castrogiovanni C and §Meraldi P Cell division: the science friction of chromosome attachment, Curr Biol., 2022, 32, R744-746 doi: 10.1016/j.cub.2022.05.045.

#Le Roux-Bourdieu M, #Dwivedi D, Harry D and Meraldi P. PLK1 controls centriole distal appendage formation and centrobin removal via independent pathways. J. Cell Sci, 2022, 135, jcs259120


Guerreiro A, De Sousa F, Liaudet N, Ivanova D, Eskat A and Meraldi P. WDR62 localizes katanin at spindle poles to ensure synchronous chromosome segregation J. Cell Biol., 2021, 220, e202007171 doi: 10.1083/jcb.202007171.

Ducrey E, Castrogiovanni C, §Meraldi P and §Nowak-Sliwinska P Forcing dividing cancer cells to die; low-dose drug combinations to prevent spindle pole clustering. Apoptosis, 2021, 26, 248-52 doi: 10.1007/s10495-021-01671-3


#Weiss A, #Le Roux Bourdieu M, Zoetmelk M, Ramzy GM, Rausch M, Harry D, Miljkovic-Licina M, Falamaki K, Wehrle-Haller B, Meraldi P and Nowak-Sliwinska P Identification of a synergistic multi-drug combination active in cancer cells via the prevention of spindle pole clustering Cancers, 2019, 11, 1626

Bondaz A, Cirillo L, §Meraldi P and §Monica G Cell polarity dependent centrosome separation in the C. elegans embryo J. Cell Biol., 2019, 218, 4112-26

Dudka D, Castrogiovanni C, Liaudet N, Vassal H and Meraldi P Spindle length-dependent HURP localization allows centrosomes to control kinetochore-fiber plus -end dynamics Curr Biol, 2019, 29, 3563-3578.e6

Wilhelm T, #Olziersky A-M, Harry D, De Sousa F, Vassal H, Eskat A and §Meraldi P Mild replication stress causes chromosome mis-segregation via premature centriole disengagement Nature Commun., 2019, 10, 3585 DOI: 10.1038/s41467-019-11584-0

Berndsen R, Castrogiovanni C, Weiss A, Rausch M, Dallinga M, Milijkovic-Licina M, Klaasen I, Meraldi P, van Beijnum J and Nowak-Sliwinska P Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression Br. J. of Cancer, 2019, 121, 139-49

Meraldi P Bub1 – the zombie protein that CRISPR cannot kill, EMBO J., 2019,  38: e101912

Guerreiro A and Meraldi P. AA344 and AA345 antibodies recognize the microtubule network in human cells by immunofluorescence. Antibody reports, 2019, e17


#Dudka D, #Noatynska A, Smith CA, Liaudet, N, McAinsh AD and Meraldi P. Complete microtubule-kinetochore occupancy favours segregation of merotlic attachments Nature Commun., 2018, DOI: 10.1038/s41467-018-04427-x

#Olziersky AM, #Smith CA, Burroughs N, §McAinsh AD and §Meraldi P. Mitotic live cell imaging at different time scales Methods in Cell Biology, 2018, i145:1-27. doi: 10.1016/bs.mcb.2018.03.009

Lee BY, Schwager F, §Meraldi P and §Gotta M. p37/UBXN2B regulates spindle orientation by limiting cortical recruitment via PP1/Repo-Man J. Cell Biol., 2018, 217, 483-493

Labidy-Galy IS, Olivier T, Rodrigues M, Ferraioli D., Bodmer A, Petignat P, Rak B, Chopin N, Tredan O, Heudel PE, Stuckelberger S, Meeus P, Meraldi P, Viassolo V, Ayme A, Chappuis P, Stern MH, Houdayer C, Stoppa-Lyonnet D, Buisson A, Golmard L, Bonadona V and Ray-Coquad I. Location of mutations in BRCA2 gene and survival in patients with ovarian cancer Clinical Cancer Research., 2018, 24, 326-333


#Gulluni F, #Martini M, #De Santis MC, Campa CC, Ghigo A, Margaria JP, Ciraolo E, Franco I, Ala U, Annaratone L, Disalvatore D, Bertalot G, Viale G, Noatynska A, Compagno M, Sigismund S, Montemurro F, Thelen M, Meraldi P, Marchiò C, Pece S, Sapino A,Chiarle R, Di Fiore PP and Hirsch E. Mitotic spindle assembly and genomic stability in breast cancer require PIK3-C2a scaffolding function Cancer Cell, 2017, 32, 444-459

Cirillo L, §Gotta M and §Meraldi P. The elephant in the room: role of microtubules in cancer. Book chapter in Cell Division Machinery and Disease, Adv Exp Med Biol., 2017, 93-124

Dudka D and Meraldi P. Symmetry does not come for free – cellular mechanisms to achieve a symmetric cell division. Book chapter in Asymmetric Cell Division in Development, Differentiation and Cancer, Results Probl Cell Differ., 2017, 61, 301-321

Berndsen RH, Weiss A, Abdul UK, Wong TJ, Meraldi P, Griffioen AW, Dyson PJ, Nowak-Sliwinska P. Combination of ruthenium(II)-arene complex [Ru(η(6)-p-cymene)Cl2(pta)] (RAPTA-C)  and the epidermal growth factor receptor inhibitor erlotinib results in efficient angiostatic and antitumor activity. Sci Rep., 2017  doi: 10.1038/srep43005.



Redli P, Gasic I, Meraldi P, Nigg EA, Santamaria A. The Ska complex promotes Aurora B activity to ensure chromosome biorientation. J. Cell Biol., 2016,

Meraldi P. Centrosomes in spindle organization and chromosome segregation: a mechanistic view, Chromosome Res, 2016, 24, 19-34




Meraldi P. Two Ways to Get Mad at Kinetochores, Dev Cell, 2015, 35, 535-6

Gasic I, Nerurkar P and Meraldi P. Centrosome age regulates kinetochore microtubule stability and biases chromosome mis-segregation, Elife, 2015, doi: 10.7554/eLife.07909

Centrosome age regulates kinetochore microtubule stability and biases chromosome mis-segregation - See more at:
Centrosome age regulates kinetochore microtubule stability and biases chromosome mis-segregation - See more at:
Centrosome age regulates kinetochore microtubule stability and biases chromosome mis-segregation - See more at:

Tan CH, #Gasic I, #Huber-Reggi SP, Dudka D, Barisic M, Maiato H and Meraldi P. The equatorial position of the metaphase plate ensures symmetric cell divisions, Elife, 2015, doi: 10.7554/eLife.05124

Mouysset J, Gilberto S, Meier MG, Lampert F, Belwal M, Meraldi P and Peter M. CRL4RBBP7 is required for efficient CENP-A deposition at centromeres, J. Cell Sci., 2015, 128, 1732-45



Chapard C, Meraldi P, Gleich T, Bachmann D, Hohl D, and Huber M. The TRAF-interacting protein TRAIP is a regulator of the spindle assembly checkpoint, J. Cell Sci., 2014, 127, 5149-56

Maiolica A, De Medina Redondo M, Schoof EM, Chaikuad A, Villa F, Gatti M, Jeganatgan S, Lou, HJ, Novy K, Hauri S, Toprak UH, Herzog F, Meraldi P, Penengo L, Turk BE, Knapp S, Linding R and Aebersold R. Modulation of the chromatin phosphoproteome by the Haspin protein kinase, Mol Cell Proteomics, 2014, 13, 1724-40

Turgay Y, Champion L, Balazs C, Held M, Toso A, Gerlich D, Meraldi P and Kutay U. SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown, J. Cell Biol., 2014, 204, 1099-109



#Vladimirou E, #Mchedlishvili N, #Gasic I, Samora CP, Armond JW, Holtackers R, §Meraldi P and §McAinsh AD. Non-autonomous movements of chromosomes in mitosis, Dev. Cell, 2013, 27, 60-71

§Charnley M, Anderegg F, Holtackers R, Textor M and Meraldi P. Effect of cell shape and dimensionality on spindle orientation and mitotic timing, Plos One, 2013, 8, e66918

Kress E, #SchwagerF, #Holtackers R, #Seiler J, Prodon F, Zanin E, Eiteneuer A, Toya M, Sugimoto A, Meyer HH, Meraldi P and Gotta M. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A kinase, J. Cell Biol., 2013, 201, 559-75

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KHA, Copenhaver GP, DeLuca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LET, Karpen G, Kops GJPL, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O’Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K and Cleveland DW. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant, Chromosome Res, 2013, PMID 23580138



Noatynska A, §Gotta M and §Meraldi P.  Mitotic Spindle (Dis)orientation and DISease: cause or consequence, 2012, J. Cell Biol., 2012, 199, 1025-35

Eskat A, Deng W, Hofmeister A, Rudolphi S, Emmerth S, Hellwig D, Ulbricht T, Döring V, Bancroft JM, McAinsh AD, Cardoso MC, Meraldi P, Hoischen C, Leonhardt H and Diekmann S. Step-Wise Assembly, Maturation and Dynamic Behavior of the Human CENP-P/O/R/Q/U Kinetochore Subcomplex, Plos One, 2012, 7, e44717

Wandke C, Barisic M, Sigl R, Rauch V, Wolf F, Amaro AC, Tan CH, Pereira AJ, Kutay U, Maiato H, Meraldi P and Geley S. Human chromokinesins promote congression and spindle microtubule dynamics during mitosis, J. Cell Biol., 2012, 198, 847-63

Logarinho E, Maffini S, Barisic M, Marques A, Toso A, Meraldi P and Maiato H. CLASPs ensure spindle pole integrity in response to kinetochore traction forces on congressing chromosomes. Nat Cell. Biol., 2012, 14, 295-303

#Mchedlishvili N, #Wieser S, Holtackers R, Moussyet J, Belwal M and Meraldi P. Kinetochores accelerate centrosome separation to ensure efficient alignment and segregation of chromosomes. J. Cell Sci., 2012, 125, 906-18



Hagan R, Maniak MS, Buch HK, Meier MG, Meraldi P, §Shah JS, §Sorger PK. p31comet acts to ensure timely checkpoint silencing subsequent to kinetochore attachment. MBoC, 2011,22, 4236-46

Hellwig D, Emmerth S, Ulbricht T, Doering V, Hoischen C, Martin R, Samora C, McAinsh AD, Carroll C, Straight A, Meraldi P and Diekmann S. Dynamics of CENP-N kinetochore binding during the cell cycle. J. Cell Sci., 2011, 124, 3871-83

Meraldi P. Keeping Kinetochores on track. Eur. J. Cell Biol., 2011, 91, 103-6

§McAinsh AD and §Meraldi P. The CCAN complex: linking centromere specification to control of kinetochore microtubule-dynamics. Sem. Cell Dev. Biol., 2011,22, 946-52

§De Medina-Redondo M and §Meraldi P. The spindle assembly checkpoint: clock or domino? Results Prol. Cell Diff., 2011, 53 ,75-91

Thoma C, Toso A, Meraldi P and Krek W. Mechanisms of aneuploidy and its suppression by tumor suppressor proteins. Swiss Med Wkly, 2011, 141,w13170



Amaro AC, Samora C, Holtackers R, Wang E, Kingston IJ, Alonso M, Lampson M, §McAinsh AD, §Meraldi P. Molecular control of kinetochore-microtubule dynamics and chromosome oscillations. Nat. Cell Biol., 2010, 12, 319-29

#Jaqaman K, #King EM, #Amaro AC, #Winter JR, Dorn J, Elliot H, Mchedlishvili N, McClelland S, Porter IM, Posch M, Toso A, §Danuser G, §McAinsh AD, §Meraldi P and §Swedlow JR. Quantitative 4D live-cell imaging reveals regulation of kinetochore alignment within the metaphase plate by centromere stiffness and microtubule depolymerases. J. Cell Biol.,2010, 188, 665-79

§Kops GJPL, Saurin AT and §Meraldi P. Finding the middle ground: How kinetochores power chromosome congression. Cell. and Mol. Life Sciences, 2010, 67, 2145-61



#Thoma CR, #Toso A, Gutbordt KL, Reggi SP, Frew IJ, Schraml P, Hergovich A, Moch H, §Meraldi P and §Krek W. VHL loss causes spindle mis-orientation and chromosome instability. Nat. Cell Biol., 2009,11, 994-1001

Klebig C, Korinth D and Meraldi P. Bub1 regulates chromosome segregation in a kinetochore independent manner. J. Cell Biol., 2009, 185, 841-58

#Toso A, #Winter JR, Garrod AJ, Amaro AC, §Meraldi Pand §McAinsh AD. Kinetochores-generated pushing forces separate centrosomes during bipolar spindle assembly. J. Cell Biol., 2009, 184, 365-72

Thoma C, Toso A, §Meraldi P and §Krek W. Double-trouble in mitosis caused by von Hippel-Lindau tumour suppressor protein inactivation. Cell Cycle, 2009, 8, 3619-20

De Medina-Redondo M and Meraldi P. A life outside kinetochores for Bub1 kinases? Cell Cycle, 2009, 8, 3250-1

Amaro AC and Meraldi P. COMA puts Ipl1-Sli15 at the right spot. Cell Cycle, 2009, 8, 2484-8

Klebig C, Toso A, Borusu S and Meraldi P. Probing kinetochore function: spindle checkpoint and chromosome congression. Methods in Molecular Biology, 2009, 545, 205-20



#McClelland SE, #Borusu S, Amaro AC, Winter JR, Belwal M, §McAinsh AD and §Meraldi P. The CENP-ANAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. EMBO J., 2007, 26, 5033-47



§#McAinsh AD, §#Meraldi P, #Draviam VM, Toso A and Sorger PK. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO J., 2006, 25, 4033-49

#Meraldi P, #McAinsh AD, Rheinbay E and Sorger PK. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol., 2006, 7, R23


Publications as pre-and post-doctoral researcher

#equal contribution


Meraldi P and Sorger PK. A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J., 2005, 24, 1621-33

Rapley J, Baxter JE, Wattam SL, Casenghi M, Meraldi P, Nigg EA, and Fry AM. Coordinate regulation of the mother centriole component Nlp by Nek2 and Plk1 protein kinases. MCB, 2005, 25, 1309-24



#Meraldi P, #Draviam VM and Sorger PK. Timing and checkpoint in the regulation of mitotic progression. Dev Cell., 2004, 7, 45-60                                                           

Meraldi P, Honda R and Nigg EA. Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Gen Dev., 2004, 15, 29-36



#Casenghi M, #Meraldi P, Weinhart U, Duncan PI, Koerner R, and Nigg EA. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell., 2003,  5, 113-25



Meraldi P and Nigg EA The centrosome cycle. FEBS letter, 2002, 521, 9-13

Kufer TA, Sillje HH, Koerner R, Gruss OJ, Meraldi P and Nigg EA. Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol., 2002, 158, 617-23.

Meraldi P, Honda R and Nigg EA. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53(-/-) cells. EMBO J., 2002, 21, 483-92



Meraldi P, and Nigg EA. Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. J Cell Sci., 2001, 114, 3749-57



Mayor T, Meraldi P, Stierhof YD, Nigg EA and Fry AM. Protein kinases in control of the centrosome cycle. FEBS letter, 1999, 452, 92-95

Meraldi P, Lukas J, Fry AM, Bartek J and Nigg EA. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-Cyclin A. Nat. Cell Biol., 1999, 1, 88-93



Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K and Nigg EA. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J. Cell. Biol., 1998, 141, 1563-1574

Fry AM, Meraldi P and Nigg EA. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J., 1998, 17, 470-481