All-heteroatom carbon stereocenters
Chiral tetraoxa and azatrioxa carbon spiro stereocenters are studied as single enantiomers and display very high enantiomerization barriers
Modern Cyclization Methodology
Densely-functionalized bicyclic cyclopentanones thanks to photoinduced 6-endo-trig Giese additions and aldol cyclizations
Cationic and neutral radical helicenes
Triple para-Functionalized Cations and Neutral Radicals of Enantiopure Diaza [4]Helicenes
[3+6+3+6] macrocyclization
With Pd(II)-catalysis, macrocycles are prepared by [3+6+3+6] condensation of cyclic ethers with aryl alpha-diazo-beta-ketoesters
Chiral boramidine
Axially-chiral boramidines showcase deep-blue fluorescence (Φ up to 94%), and gabs and glum |10-3| values
Multistep synthesis
Oxa/aza benzonorbornadienes and diazomalonates afford polycyclic pyrazolidines
Two-photon spectroscopy
Bright tris para-MeO helicenes are designed for 2-photon excitation and proved competent under both 1PE and 2PE microscopy.
N-H carbene insertion
General N-H insertion reactivity of acceptor-acceptor diazo malonate reagents under Ir-catalysis
Supramolecular aggregation
Chiral disulfide bispyrene macrocycle with excimer aggregation-induced emission
La recherche dans le groupe Lacour vise la préparation de sels et d'ylures chiraux et leur utilisation dans la chimie de synthèse (asymétrique) au sens large.
Pour plus d'informations, voir Recherches (en anglais)