2023 DECEMBER

Prediction of transporter function

J Pharmacol Exp Ther. 2023;387:131-134. A novel approach to predicting Organic Anion Transporting Polypeptide function in human hepatic drug disposition and biliary clearance. Lash LH. PubMed

J Pharmacol Exp Ther. 2023;387:135-149. Quantitative prediction of OATP-mediated disposition and biliary clearance using human liver chimeric mice. Miyake T, Tsutsui H, Hirabayashi M, Tachibana T. PubMed

Clin Pharmacol Ther. 2023 Sep 1. TICBase: Integrated resource for data on drug and environmental chemical interactions with mammalian drug transporters. Michel ME, Wen CC, Yee SW, Giacomini KM, Hamdoun A, Nicklisch SCT. PubMed

Drug Metab Rev. 2023;55:343-370. Drug transporters in drug disposition - the year 2022 in review. Chothe PP, Mitra P, Nakakariya M, Ramsden D, Rotter CJ, Sandoval P, Tohyama K. PubMed

Drug Metab Dispos. 2023;51:1591-1606. Challenges and opportunities for in vitro-in vivo extrapolation of Aldehyde Oxidase-mediated clearance: Toward a roadmap for quantitative translation. Izat N, Bolleddula J, Abbasi A, Cheruzel L, Jones RS, Moss D, Ortega-Muro F, Parmentier Y, Peterkin VC, Tian DD, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D. PubMed

Transporter clearance
Mol Pharmacol. 2023;104:255-265. Molecular mechanisms of Organic Anion Transporting Polypeptide-mediated Organic Anion clearance at the blood-cerebrospinal fluid barrier. Sun A, Hagenbuch B, Kelly EJ, Wang J. PubMed

Regulation of transporters

Biochem Pharmacol. 2023;215:115695. Palmitoylation of solute carriers. Villanueva CE, Hagenbuch B. PubMed

Heliyon. 2023;9:e21009. Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease. Dellbrügge F, Jesse LD, Medyukhina A, Liu N, Neugebauer S, Freißmuth M, Höppener S, Figge MT, Morrison H, Riecken LB, Press AT. PubMed

Xenobiotica. 2023;53:559-571. Hyperoside ameliorates cisplatin-induced acute kidney injury by regulating the expression and function of Oat1. Yuan W, Kou S, Ma Y, Qian Y, Li X, Chai Y, Jiang Z, Zhang L, Sun L, Huang X. PubMed

Hepatic cell composition and liver fibrosis
Comput Struct Biotechnol J. 2023;21:4361-4369. Proteome deconvolution of liver biopsies reveals hepatic cell composition as an important marker of fibrosis. Handin N, Yuan D, Ölander M, Wegler C, Karlsson C, Jansson-Löfmark R, Hjelmesæth J, Åsberg A, Lauschke VM, Artursson P. PubMed

Experimental models
Environ Pollut. 2023:123047. Hepatotoxicity of cyanotoxin microcystin-LR in human: Insights into mechanisms of action in the 3D culture model Hepoid-HepaRG. Chowdhury RR, Rose S, Ezan F, Sovadinová I, Babica P, Langouët S. PubMed

Int J Mol Sci. 2023;24:16391. A regulator role for the ATP-Binding Cassette Subfamily C Member 6 Transporter in HepG2 Cells: Effect on the dynamics of Cell-Cell and Cell-Matrix Interactions. Matera I, Miglionico R, Abruzzese V, Marchese G, Ventola GM, Castiglione Morelli MA, Bisaccia F, Ostuni A. PubMed

J Biosci Bioeng. 2023;In press. Coculture model of a liver sinusoidal endothelial cell barrier and HepG2/C3a spheroids-on-chip in an advanced fluidic platform. Messelmani T, Le Goff A, Soncin F, Souguir Z, Merlier F, Maubon N, Legallais C, Leclerc E, Jellali R. PubMed

Liver cholestasis
Phytomedicine. 2024 Jan;122:155124. Wedelolactone alleviates cholestatic liver injury by regulating FXR-bile acid-NF-κB/NRF2 axis to reduce bile acid accumulation and its subsequent inflammation and oxidative stress. Wang MQ, Zhang KH, Liu FL, Zhou R, Zeng Y, Chen AL, Yu Y, Xia Q, Zhu CC, Lin CZ. PubMed

Toxicol Pathol. 2023;In press. Hepatic Bile Acid Transporters and drug-induced hepatotoxicity. Saran C, Brouwer KLR. PubMed

Transporter structure

Nat Commun. 2023;14:7296. Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Liu H, Irobalieva RN, Kowal J, Ni D, Nosol K, Bang-Sørensen R, Lancien L, Stahlberg H, Stieger B, Locher KP. PubMed

Prediction of hepatic concentrations
Clin Pharmacol Ther. 2023;In press. Successful prediction of human hepatic concentrations of transported drugs using the proteomics-informed relative expression factor approach. Yin M, Balhara A, Marie S, Tournier N, Gáborik Z, Unadkat JD. PubMed