2020 DECEMBER

A tribute to Peer Artursson

J Pharm Sci. 2020;In press. A Tribute to Professor Per Artursson - Scientist, explorer, mentor, innovator, and giant in Pharmaceutical Research. Matsson P, Baranczewski P, Giacomini KM, Andersson TB, Palm J, Palm K, Charman WN, Bergström CAS. PubMed

Hepatobiliary imaging

J Clin Pharmacol. 2020;In press. Unusual distribution kinetics of Gadoxetate in healthy human subjects genotyped for OATP1B1: Application of population analysis and a minimal Physiological-Based Pharmacokinetic model. Weiss M, Siegmund W. PubMed

Transporter quantification

Clin Pharmacol Ther. 2020;In press. Liquid biopsy enables quantification of the abundance and interindividual variability of hepatic enzymes and transporters. Achour B, Al-Majdoub ZM, Grybos-Gajniak A, Lea K, Kilford P, Zhang M, Knight D, Barber J, Schageman J, Rostami-Hodjegan A. PubMed

FEBS Lett. 2020;In press. Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin. Al-Majdoub ZM, Achour B, Couto N, Howard M, Elmorsi Y, Scotcher D, Alrubia S, El-Khateeb E, Vasilogianni AM, Alohali N, Neuhoff S, Schmitt L, Rostami-Hodjegan A, Barber J. PubMed

Arch Toxicol. 2020;In press. Cross-species analysis of hepatic cytochrome P450 and transport protein expression. Hammer H, Schmidt F, Marx-Stoelting P, Pötz O, Braeuning A. PubMed

J Pharm Sci. 2020;In press. Differential detergent fractionation of membrane protein from small samples of hepatocytes and liver tissue for quantitative proteomic analysis of drug metabolizing enzymes and transporters. Qasem RJ, Fallon JK, Nautiyal M, Mosedale M, Smith PC. PubMed

Drug-induced liver injury

Clin Pharmacol Ther. 2020; In press. Clinical characteristics and outcome of Drug-Induced Liver Injury in the older patients: From the young-old to the oldest-old. Weersink RA, Alvarez-Alvarez I, Medina-Cáliz I, Sanabria-Cabrera J, Robles-Díaz M, Ortega-Alonso A, García-Cortés M, Bonilla E, Niu H, Soriano G, Jimenez-Perez M, Hallal H, Blanco S, Kaplowitz N, Lucena MI, Andrade RJ. PubMed

Hum Exp Toxicol. 2020;In press. Effects of psoralen on hepatic bile acid transporters in rats. Huang J, Wang Q, Chen M, Bi Y, Shi H, Zhou K. PubMed

Natural product-drug interactions

Clin Pharmacol Ther. 2020;In press. Assessing transporter-mediated Natural Product-Drug Interactions via in vitro-in vivo extrapolation: Clinical evaluation with a probe cocktail. Nguyen JT, Tian DD, Tanna RS, Hadi DL, Bansal S, Calamia JC, Arian CM, Shireman LM, Molnár B, Horváth M, Kellogg JJ, Layton ME, White JR, Cech NB, Boyce RD, Unadkat JD, Thummel KE, Paine MF. PubMed

Liver physiopathology

Arch Toxicol. 2020;In press. Novel testing strategy for prediction of rat biliary excretion of intravenously administered estradiol-17β glucuronide. Noorlander A, Fabian E, van Ravenzwaay B, Rietjens IMCM. PubMed

Hepatology. 2020;In press. Targeting the four pillars of enterohepatic bile salt cycling; lessons from genetics and pharmacology. Kunst RF, Verkade HJ, Oude Elferink RPJ, van de Graaf SFJ. PubMed

Drug-drug interactions

Int J Toxicol. 2020;39:518-529. Assessment of statin interactions with the human NTCP transporter using a novel fluorescence assay. Wang Y, Wilkerson M, Li J, Zhang W, Owens A, Wright S, Hidalgo I. PubMed

J Pharm Sci. 2020;In press. Ito S, Lee W, Park JE, Yasunaga M, Mori A, Ohtsuki S, Sugiyama Y. Transient, tunable expression of NTCP and BSEP in MDCKII Cells for kinetic delineation of the rate-determining process and inhibitory effects of Rifampicin in hepatobiliary transport of Taurocholate. PubMed

Clin Pharmacol Ther. 2020. Organic Anion Transporting Polypeptide inhibition dramatically increases plasma exposure but not pharmacodynamic effect nor inferred hepatic intracellular exposure of Firsocostat. Kirby BJ, Lutz JD, Yue MS, Garrison KL, Qin AR, Ampaw L, Beysen C, Myers RP, Kearney BP, Mathias A. PubMed

Drug Metab Dispos. 2020;48:1264-1270. Calibrating the in vitro-in vivo correlation for OATP-mediated Drug-Drug Interactions with Rosuvastatin using static and PBPK Models. Sane R, Cheung KWK, Kovács P, Farasyn T, Li R, Bui A, Musib L, Kis E, Plise E, Gáborik Z. PubMed

J Pharmacol Exp Ther. 2020;375:451-462. Interaction of halogenated Tyrosine/Phenylalanine derivatives with Organic Anion Transporter 1 in the renal handling of tumor imaging probes. Jin C, Wei L, Ohgaki R, Tominaga H, Xu M, Okuda S, Okanishi H, Kawamoto Y, He X, Nagamori S, Kanai Y. PubMed

Eur J Pharm Sci. 2021; In press. Inhibition of ABCG2/BCRP-mediated transport-correlation analysis of various expression systems and probe substrates. Sáfár Z, Kecskeméti G, Molnár J, Kurunczi A, Szabó Z, Janáky T, Kis E, Krajcsi P. PubMed

Uptake clearance

Drug Metab Dispos. 2020;In press. Effect of human plasma on hepatic uptake of Organic Anion-Transporting Polypeptide 1B substrates: Studies using transfected cells and primary human hepatocytes. Bi YA, Ryu S, Tess DA, Rodrigues AD, Varma MVS. PubMed

J Pharm Sci. 2020;In press. Evaluation of hepatic uptake of OATP1B substrates by short term-cultured plated human hepatocytes: Comparison with isolated suspended hepatocytes. Yoshikado T, Lee W, Toshimoto K, Morita K, Kiriake A, Chu X, Lee N, Kimoto E, Varma MVS, Kikuchi R, Scialis RJ, Shen H, Ishiguro N, Lotz R, Li AP, Maeda K, Kusuhara H, Sugiyama Y. PubMed

AAPS J. 2020;23:1. Albumin-mediated uptake improves human clearance prediction for hepatic uptake transporter substrates aiding a mechanistic in vitro-in vivo extrapolation (IVIVE) strategy in discovery research. Li N, Badrinarayanan A, Ishida K, Li X, Roberts J, Wang S, Hayashi M, Gupta A. PubMed

AAPS J. 2020;22:133. Cell-to-Medium concentration ratio overshoot in the uptake of statins by human hepatocytes in suspension, but not in monolayer: Kinetic analysis suggesting a partial loss of functional OATP1Bs. Lee W, Koyama S, Morita K, Kiriake A, Kikuchi R, Chu X, Lee N, Scialis RJ, Shen H, Kimoto E, Tremaine L, Ishiguro N, Lotz R, Maeda K, Kusuhara H, Sugiyama Y. PubMed

Drug Metab Dispos. 2020;In press. Prediction of transporter-mediated Rosuvastatin hepatic uptake clearance and drug interaction in humans using Proteomics-Informed REF approach. Kumar V, Yin M, Ishida K, Salphati L, Hop CECA, Rowbottom C, Xiao G, Lai Y, Mathias A, Chu X, Humphreys WG, Liao M, Nerada Z, Szilvásy N, Heyward S, Unadkat JD. PubMed

Drug Metab Dispos. 2020;48:1380-1392. Differences in Metformin and Thiamine uptake between human and mouse Organic Cation Transporter 1: Structural determinants and potential consequences for intrahepatic concentrations. Meyer MJ, Tuerkova A, Römer S, Wenzel C, Seitz T, Gaedcke J, Oswald S, Brockmöller J, Zdrazil B, Tzvetkov MV. PubMed

Drug Metab Dispos. 2020;48:1271-1282. Scaling factors for clearance in adult liver cirrhosis. El-Khateeb E, Achour B, Scotcher D, Al-Majdoub ZM, Athwal V, Barber J, Rostami-Hodjegan A. PubMed

Transporter substrates

J Pharm Sci. 2020;In press. A novel fluorescence-based method to evaluate ileal apical sodium-dependent bile acid transporter ASBT. Zhu Q, Komori H, Imamura R, Tamai I. PubMed

Transporter regulation

Drug Metab Pharmacokinet. 2020;35:515-521. Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24. Liu W, Nakano M, Nakanishi T, Nakajima M, Tamai I. PubMed

Am J Physiol Gastrointest Liver Physiol. 2020;In press. Long-term trans-inhibition of the hepatitis B and D virus receptor NTCP by taurolithocholic acid. Lowjaga KAA, Kirstgen M, Müller SF, Goldmann N, Lehmann F, Glebe D, Geyer J. PubMed

Drug Metab Pharmacokinet. 2020;35:555-562. 6-Hydroxyindole is an endogenous long-lasting OATP1B1 inhibitor elevated in renal failure patients. Masuo Y, Fujita KI, Mishiro K, Seba N, Kogi T, Okumura H, Matsumoto N, Kunishima M, Kato Y. PubMed

J Biol Chem. 2020;in press. A clinically-relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position. Ruggiero MJ, Malhotra S, Fenton AW, Swint-Kruse L, Karanicolas J, Hagenbuch B. PubMed

Drug-drug-gene interactions

Clin Pharmacol Ther. 2020;In press. Physiologically based precision dosing approach for Drug-Drug-Gene interactions: A Simvastatin network analysis. Wojtyniak JG, Selzer D, Schwab M, Lehr T. PubMed

Pharmacokinetic modelling

Clin Pharmacol Ther. 2020;In press. Physiologically Based Pharmacokinetic Modeling in renal and hepatic impairment populations: A pharmaceutical industry perspective. Heimbach T, Chen Y, Chen J, Dixit V, Parrott N, Peters SA, Poggesi I, Sharma P, Snoeys J, Shebley M, Tai G, Tse S, Upreti VV, Wang YH, Tsai A, Xia B, Zheng M, Zhu AZX, Hall S. PubMed