2022 APRIL

ICT publication

Clin Pharmacol Ther. 2022;In press.  Regulation of drug transport proteins - From mechanisms to clinical impact; A white paper on behalf of the ITC. Brouwer KLR, Evers R, Hayden E, Hu S, Li CY, Meyer Zu Schwabedissen HE, Neuhoff S, Oswald S, Piquette-Miller M, Saran C, Sjöstedt N, Sprowl J, Stahl SH, Yue W. PubMed

Clin Pharmacol Ther. 2022 ;In press. New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium. Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen E, Kroetz DL, Miller MA, Gozalpour E, Chu X. PubMed

Hepatic clearance

Eur J Pharm Sci. 2022;172:106134. A myth of the well-stirred model: Is the well-stirred model good for high clearance drugs? Dong J, Park MS. PubMed

Pharm Res. 2022;in press. In vitro - in vivo extrapolation of hepatic clearance in preclinical species. Tess DA, Ryu S, Di L. PubMed

Transporters and species

Drug Metab Pharmacokinet. 2022;43:100437. Systematic identification and characterization of cynomolgus macaque solute carrier transporters. Uno Y, Yamazaki H. PubMed

Drug Metab Dispos. 2022;50:299-319. Cynomolgus monkey as an emerging animal model to study drug transporters: In vitro, in vivo, in vitro-to-in vivo translation. Shen H, Yang Z, Rodrigues AD. PubMed

Pharmacogenetics of transporters

Clin Pharmacol Ther. 2022 ;In press. The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-associated musculoskeletal symptoms.  Cooper-DeHoff RM, Niemi M, Ramsey LB, Luzum JA, Tarkiainen EK, Straka RJ, Gong L, Tuteja S, Wilke RA, Wadelius M, Larson EA, Roden DM, Klein TE, Yee SW, Krauss RM, Turner RM, Palaniappan L, Gaedigk A, Giacomini KM, Caudle KE, Voora D. PubMed

Clin Pharmacol Ther. 2022 ;In press. SLCO1B1*5 Allele is associated with Atorvastatin discontinuation and adverse muscle symptoms in the context of routine care. Voora D, Baye J, McDermaid A, Narayana Gowda S, Wilke RA, Nicole Myrmoe A, Hajek C, Larson EA. PubMed

Transporter-dependent DDI

Clin Pharmacol Ther. 2022 ;In press. Effect of cyclosporin A and impact of dose staggering on OATP1B1/1B3 endogenous substrates and drug probes for assessing clinical drug interactions. Mochizuki T, Zamek-Gliszczynski MJ, Yoshida K, Mao J, Taskar K, Hirabayashi H, Chu X, Lai Y, Takashima T, Rockich K, Yamaura Y, Fujiwara K, Mizuno T, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. PubMed

Clin Pharmacol Ther. 2022 ;In press. Evaluation of the effect of Abrocitinib on drug transporters by integrated use of probe drugs and endogenous biomarkers. Vourvahis M, Byon W, Chang C, Le V, Diehl A, Graham D, Tripathy S, Raha N, Luo L, Mathialagan S, Dowty M, Rodrigues AD, Malhotra B. PubMed

Pharm Res. 2022 ;In press. High throughput screening of a prescription drug library for inhibitors of Organic Cation Transporter 3, OCT3. Chen EC, Matsson P, Azimi M, Zhou X, Handin N, Yee SW, Artursson P, Giacomini KM. PubMed

Clin Pharmacol Ther. 2022 ;In press. Blockade of organic anion transport in humans after treatment with the drug probenecid leads to major metabolic alterations in plasma and urine. Granados JC, Bhatnagar V, Nigam SK. PubMed

Proteomics of drug-metabolising enzymes and obesity

Clin Pharmacol Ther. 2022 ;In press. Drug disposition protein quantification in matched human jejunum and liver from donors with obesity. Wegler C, Wiśniewski JR, Robertsen I, Christensen H, Kristoffer Hertel J, Hjelmesaeth J, Jansson-Löfmark R, Åsberg A, Andersson TB, Artursson P. PubMed

Transporters of the kidney

Physiol Rev. 2022;102:993-1024. Regulation of solute carriers oct2 and OAT1/3 in the kidney: a phylogenetic, ontogenetic, and cell dynamic perspective. Pou Casellas C, Jansen K, Rookmaaker MB, Clevers H, Verhaar MC, Masereeuw R. PubMed

Transporter functions

Front Physiol. 2022;13:859294. Multidrug Resistance-Associated Protein 2 deficiency aggravates estrogen-induced impairment of bile acid metabolomics in rats. Alaei Faradonbeh F, Lastuvkova H, Cermanova J, Hroch M, Nova Z, Uher M, Hirsova P, Pavek P, Micuda S. PubMed

Drug Metab Dispos. 2021 ;In press. Emerging roles of the Human Solute Carrier 22 family. Yee SW, Giacomini KM. PubMed

Structural plasticity of NTPC

Int J Mol Sci. 2022;23:3211. Structural plasticity is a feature of rheostat positions in the Human Na⁺/Taurocholate Cotransporting Polypeptide (NTCP). Ruggiero MJ, Malhotra S, Fenton AW, Swint-Kruse L, Karanicolas J, Hagenbuch B. PubMed

Protein-mediated uptake of OATP

Drug Metab Dispos. 2022 ;In press. Is the protein-mediated uptake of drugs by OATPs : A real phenomenon or an artifact? Yin M, Storelli F, Unadkat JD. PubMed

Bile acids and acetaminophen toxicity

J Hepatol. 2022 ;In press. Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. Ghallab A, Hassan R, Hofmann U, Friebel A, Hobloss Z, Brackhagen L, Begher-Tibbe B, Myllys M, Reinders J, Overbeck N, Sezgin S, Zühlke S, Seddek AL, Murad W, Brecklinghaus T, Kappenberg F, Rahnenführer J, González D, Goldring C, Copple IM, Marchan R, Longerich T, Vucur M, Luedde T, Urban S, Canbay A, Schreiter T, Trauner M, Akakpo JY, Olyaee M, Curry SC, Sowa JP, Jaeschke H, Hoehme S, Hengstler JG. PubMed

Modeling in liver disease

Clin Pharmacol Ther. 2022 ;In press. Considerations for physiologically based modeling in liver disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH). Murphy WA, Adiwidjaja J, Sjöstedt N, Yang K, Beaudoin JJ, Spires J, Siler SQ, Neuhoff S, Brouwer KLR. PubMed

Transporters and endotoxemia

Pharmaceuticals. 2022;15:392. Pharmacokinetic Imaging using ^99mTc-Mebrofenin to untangle the pattern of hepatocyte transporter disruptions induced by endotoxemia in rats. Marie S, Hernández-Lozano I, Le Vée M, Breuil L, Saba W, Goislard M, Goutal S, Truillet C, Langer O, Fardel O, Tournier N. PubMed