2022 JUNE
ICT publication
Clin Pharmacol Ther. 2022;In press. Regulation of drug transport proteins-from mechanisms to clinical impact: A white paper on behalf of the International Transporter Consortium. Brouwer KLR, Evers R, Hayden E, Hu S, Li CY, Meyer Zu Schwabedissen HE, Neuhoff S, Oswald S, Piquette-Miller M, Saran C, Sjöstedt N, Sprowl JA, Stahl SH, Yue W. PubMed
Clin Pharmacol Ther. 2022;In press. Transporters and toxicity: Insights from the International Transporter Consortium Workshop 4. Hafey MJ, Aleksunes LM, Bridges CC, Brouwer KR, Chien HC, Leslie EM, Hu S, Li Y, Shen J, Sparreboom A, Sprowl J, Tweedie D, Lai Y. PubMed
Clin Pharmacol Ther. 2022;In press. International Transporter Consortium. Transporters in drug development: International Transporter Consortium update on emerging transporters of clinical importance. Zamek-Gliszczynski MJ, Sangha V, Shen H, Feng B, Wittwer MB, Varma MVS, Liang X, Sugiyama Y, Zhang L, Bendayan R. PubMed
Clin Pharmacol Ther. 2022;In press. Clinical relevance of hepatic and renal P-gp/BCRP inhibition of drugs: An International Transporter Consortium perspective. Taskar KS, Yang X, Neuhoff S, Patel M, Yoshida K, Paine MF, Brouwer KLR, Chu X, Sugiyama Y, Cook J, Polli JW, Hanna I, Lai Y, Zamek-Gliszczynski M. PubMed
Transporter expression and function
Int J Mol Sci. 2021;23:255. Expression and functional contribution of different Organic Cation Transporters to the cellular uptake of Doxorubicin into human breast cancer and cardiac tissue. M, Csader S, Keiser M, Oswald S. PubMed
Clin Pharmacol Ther. 2022;In press. Clinical relevance of Organic Anion Transporting Polypeptide 1B-mediated hepatic uptake for high-permeability drugs: A perspective. Varma MVS. PubMed
Clin Pharmacol Ther. 2022;In press. Genome-wide association study of simvastatin pharmacokinetics. Mykkänen AJH, Taskinen S, Neuvonen M, Paile-Hyvärinen M, Tarkiainen EK, Lilius T, Tapaninen T, Backman JT, Tornio A, Niemi M. PubMed
Drug Metab Dispos. 2022;In press. Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic. Yadav AS, Stevison F, Kosaka M, Wong S, Kenny JR, Amory JK, Isoherranen N. PubMed
DDI and transporters
Clin Pharmacol Ther. 2022;In press. Current perspective on residual knowledge gaps in the assessment of transporter-mediated drug interactions. Yang X, Reynolds K, Madabushi R, Huang SM. PubMed
Clin Pharmacol Ther. 2022;In press. Blockade of Organic Anion Transport in humans after treatment with the drug Probenecid leads to major metabolic alterations in plasma and urine. Granados JC, Bhatnagar V, Nigam SK. PubMed
Clin Pharmacol Ther. 2022;In press. Challenges and opportunities for improved Drug-Drug Interaction predictions for renal OCT2 and MATE1/2-K transporters. Krishnan S, Ramsden D, Ferguson D, Stahl SH, Wang J, McGinnity DF, Hariparsad N. PubMed
Modeling and transporters
Drug Metab Dispos. 2022;50:541-551. Experimental and modeling evidence supporting the Trans-Inhibition mechanism for preincubation time-dependent, long-lasting inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A. Izumi S, Nozaki Y, Lee W, Sugiyama Y. PubMed
Drug Metab Dispos. 2022;In press. Estimation of fetal-to-maternal unbound steady-state plasma concentration ratio of P-Glycoprotein and/or Breast Cancer Resistance Protein substrate drugs using a maternal-fetal Physiologically Based Pharmacokinetic model. Peng J, Ladumor MK, Unadkat JD. PubMed
Clin Pharmacol Ther. 2022;In press. Coproporphyrin I as an endogenous biomarker to detect reduced OATP1B activity and shift in elimination route in chronic kidney disease. Takita H, Scotcher D, Chu X, Yee KL, Ogungbenro K, Galetin A. PubMed
Clin Pharmacol Ther. 2022;In press. Effect of chronic kidney disease on the renal secretion via Organic Anion Transporters 1/3: Implications for Physiologically-Based Pharmacokinetic modeling and dose adjustment. Tan SPF, Scotcher D, Rostami-Hodjegan A, Galetin A. PubMed
Hepatic clearance
Clin Pharmacol Ther. 2022;111:1205-1207. Rowland M, Pang KS. Hepatic clearance models and IVIVE predictions. PubMed
Drug Metab Dispos. 2022;In press. Sinusoidal uptake determines the hepatic clearance of Pevonedistat (TAK-924) as axplained by extended clearance model. Sandoval P, Chuang BC, Cohen L, Yoneyama T, Pusalkar S, Yucha RW, Chowdhury SK, Chothe PP. PubMed
Transporters and drug-endogenous marker interaction
Clin Pharmacol Ther. 2022;In press. Renal transporter-mediated drug-biomarker interactions of the endogenous substrates Creatinine and N1 -Methylnicotinamide: A PBPK modeling approach. Türk D, Müller F, Fromm MF, Selzer D, Dallmann R, Lehr T. PubMed
Bile acid transporters
Toxicol Lett. 2022;In press. Hepatic bile acid synthesis and secretion: comparison of in vitro methods. de Bruijn VMP, Wang Z, Bakker W, Zheng W, Spee B, Bouwmeester H. PubMed
Intracellular transporters
J Hepatol. 2022;In press. SLC25A47 is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, Schoonjans K. PubMed
Cells. 2022;11:1556. Is P-Glycoprotein functionally expressed in the limiting membrane of endolysosomes? A biochemical and ultrastructural study in the rat liver. Gericke B, Wienböker I, Brandes G, Löscher W. PubMed
NTCP transporter
Front Mol Biosci. 2022;9:879817. Regulation of the HBV Entry Receptor NTCP and its Potential in Hepatitis B Treatment. Li Y, Zhou J, Li T. PubMed
Nature. 2022;In press. Structure of bile acid transporter NTCP crucial for hepatitis B virus entry. Asami J, Kimura KT, Fujita-Fujiharu Y, Ishida H, Zhang Z, Nomura Y, Liu K, Uemura T, Sato Y, Ono M, Yamamoto M, Noda T, Shigematsu H, Drew D, Iwata S, Shimizu T, Nomura N, Ohto U. PubMed
Experimental model
Cell. 2022;In press. Low-density cell culture enhances hepatic function through tight junction formation in HepG2 cells. B. Tanaka-Yachi R, Aizawa K, Shimizu K, Akutsu H, Nakamura K. PubMed