2022 FEBRUARY

Hepatic clearance

Drug Metab Dispos. 2022;50:187-190. In defense of current concepts and applications of clearance in drug development and therapeutics. Rowland M, Roberts MS, Pang KS. PubMed

Clin Pharmacol Ther. 2022;In press. Prediction of hepatobiliary clearances and hepatic concentrations of transported drugs in humans using Rosuvastatin as a model drug. Storelli F, Li CY, Sachar M, Kumar V, Heyward S, Sáfár Z, Kis E, Unadkat JD. PubMed

Choleretic substrates: mechanism?

Hepatology. 2022;In press. Pastor CM. Letter to the editor: "On the mechanisms of biliary flux". PubMed

Original publication in Hepatology. 2021;74:3497-3512. On the mechanisms of biliary flux. Vartak N, Drasdo D, Geisler F, Itoh T, P J Oude Elferink R, van de Graaf SFJ, Chiang J, Keitel V, Trauner M, Jansen P, Hengstler JG. PubMed

Pharmacokinetic modelling

Toxicol Appl Pharmacol. 2022;In press. Prediction of the human pharmacokinetics of epyrifenacil and its major metabolite, S-3100-CA, by a physiologically based pharmacokinetic modeling using chimeric mice with humanized liver. Hirasawa K, Abe J, Nagahori H, Kitamoto S. PubMed

Cholestatic livers

J Appl Toxicol. 2022;In press. Farnesoid X receptor contributes to oleanolic acid-induced cholestatic liver injury in mice. Feng H, Hu Y, Zhou S, Lu Y. PubMed

Liver-on-a-chip and cellular models

Lab Chip. 2022;In press. Exploration and application of a liver-on-a-chip device in combination with modelling and simulation for quantitative drug metabolism studies. Docci L, Milani N, Ramp T, Romeo AA, Godoy P, Franyuti DO, Krähenbühl S, Gertz M, Galetin A, Parrott N, Fowler S. PubMed

J Toxicol Sci. 2022;47:39-50. HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane. Takezawa T, Uzu M. PubMed

Biol Pharm Bull. 2022;45:150-153. Directional drug transport through membrane-supported monolayers of human liver-derived cell lines. Mizoi K, Kobayashi M, Mashimo A, Matsumoto E, Masuda N, Itoh M, Ueno T, Tachiki H, Ishida S, Ogihara T. PubMed

Liver toxicity

Toxicol Appl Pharmacol. 2022;In press. Mechanism of hepatobiliary toxicity of the LPA₁ antagonist BMS-986020 developed to treat idiopathic pulmonary fibrosis: Contrasts with BMS-986234 and BMS-986278. Gill MW, Murphy BJ, Cheng PPT, Sivaraman L, Davis M, Lehman-McKeeman L. PubMed

HBV infection and NTCP

Biomedicines. 2022;10:196. Multitasking Na⁺/Taurocholate Cotransporting Polypeptide (NTCP) as a drug target for HBV infection: From protein engineering to drug discovery. Zakrzewicz D, Geyer J. PubMed

Transporter uptake function

ACS Omega. 2021;6:35844-35851. Human Organic Anion Transporting Polypeptides 1B1, 1B3, and 2B1 are involved in the hepatic uptake of Phenolsulfonphthalein. Wang Z, Li Y, Peng T, Su Y, Luo X, Han W, Zhang H, Ruan J, Gui C. PubMed

Toxicol Appl Pharmacol. 2022;435:115848. Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1. Chen J, Xue Y, Shuai X, Ni C, Fang Z, Ye L, Hong M. PubMed

Drug Metab Dispos. 2021;IN press. Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells. Lim JJ, Suh Y, Faustman EM, Cui JY. PubMed