Bruno STIEGER GROUP   SITE

  • J Pharmacol Exp Ther. 2021;377:346-357. Characterization of novel fluorescent bile salt derivatives for studying human bile salt and Organic Anion Transporters. Leuenberger M, Häusler S, Höhn V, Euler A, Stieger B, Lochner M. PubMed
  • Biochim Biophys Acta Mol Basis Dis. 2021;1867:166079. Membrane lipids and transporter function. Stieger B, Steiger J, Locher KP. PubMed
  • Nat Struct Mol Biol. 2020;27:62-70. Structure of the human lipid exporter ABCB4 in a lipid environment. Olsen JA, Alam A, Kowal J, Stieger B, Locher KP. PubMed
  • Mol Pharm. 2020;17:316-326. Measurement of Hepatic ABCB1 and ABCG2 Transport Activity with [11C]Tariquidar and PET in Humans and Mice. Hernández Lozano I, Bauer M, Wulkersdorfer B, Traxl A, Philippe C, Weber M, Häusler S, Stieger B, Jäger W, Mairinger S, Wanek T, Hacker M, Zeitlinger M, Langer O. PubMed
  • Chem Biol Interact. 2019;311:108761.Human MRP2 exports MC-LR but not the glutathione conjugate. Kaur G, Fahrner R, Wittmann V, Stieger B, Dietrich DR. PubMed
  • Oncol Rep. 2019;41:2558-2566. Organic anion‑transporting polypeptides contribute to the uptake of curcumin and its main metabolites by human breast cancer cells: Impact on antitumor activity. Jaerapong N, Jamil QA, Riha J, Milovanovic D, Krupitza G, Stieger B, Jarukomjorn K, Jäger W. PubMed
  • Mol Pharm. 2019;16:1406-1411. Effect of a common genetic variant (p.V444A) in the Bile Salt Export Pump on the inhibition of bile acid Transport by cholestatic medications. Ali I, Khalid S, Stieger B, Brouwer KLR. PubMed
  • Hepatol Commun. 2018;2:693-702. Age-dependent glycosylation of the sodium taurocholate cotransporter polypeptide: From fetal to adult human livers. Sargiacomo C, El-Kehdy H, Pourcher G, Stieger B, Najimi M, Sokal E. PubMed
  • Pharmacol Ther. 2018;189:104-122. Imaging. Imaging techniques to study drug transporter function in vivo. Tournier N, Stieger B, Langer O. PubMed   
  • Eur J Pharm Sci. 2017;106:302-312. β2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine. Mayati A, Moreau A, Denizot C, Stieger B, Parmentier Y, Fardel O. PubMed
  • J Pharm Sci. 2017;106:2295-2301. Model systems for studying the role of canalicular efflux transporters in drug-induced cholestatic liver disease. Stieger B, Mahdi ZM. PubMed
  • Int J Mol Sci. 2017;18 pii: E764. Protein Kinases C-mediated regulations of drug transporter activity, localization and expression. Mayati A, Moreau A, Le Vée M, Stieger B, Denizot C, Parmentier Y, Fardel O. PubMed
  • Toxicol In Vitro. 2017;40:34-44. Inhibition of SLC drug transporter activities by environmental bisphenols. Bruyere A, Hubert C, Le Vee M, Chedik L, Sayyed K, Stieger B, Denizot C, Parmentier Y, Fardel O. PubMed
  • Drug Metab Dispos. 2017;45:166-173. Impact of Organic Cation Transporters (OCT-SLC22A) on differential diagnosis of intrahepatic lesions. Visentin M, van Rosmalen BV, Hiller C, Bieze M, Hofstetter L, Verheij J, Kullak-Ublick GA, Koepsell H, Phoa SS, Tamai I, Bennink RJ, van Gulik TM, Stieger B. PubMed
  • Annu Rev Pharmacol Toxicol. 2017;57:399-416. Intestinal and hepatocellular transporters: Therapeutic effects and drug interactions of herbal supplements. Stieger B, Mahdi ZM, Jäger W. PubMed
  • Pharm Res. 2017;34:2336-2348. Role of the OATP transporter family and a Benzbromarone-sensitive efflux transporter in the hepatocellular disposition of Vincristine. Nicolaï J, Thevelin L, Bing Q, Stieger B, Chanteux H, Augustijns P, Annaert P. PubMed
  • Toxicology. 2016;363-364:58-71. Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate. Sayyed K, Vee ML, Abdel-Razzak Z, Jouan E, Stieger B, Denizot C, Parmentier Y, Fardel O. PubMed
  • PLoS One. 2016;11:e0158033. Proteomic analysis of the rat canalicular membrane reveals expression of a complex system of P4-ATPases in liver. Chaubey PM, Hofstetter L, Roschitzki B, Stieger B. PubMed
  • J Pharm Sci. 2016;105:106-12. doi: 10.1016/j.xphs.2015.11.014. Influence of 24-nor-ursodeoxycholic acid on hepatic disposition of [(18)F]ciprofloxacin, a Positron Emission Tomography study in mice. Wanek T, Halilbasic E, Visentin M, Mairinger S, Römermann K, Stieger B, Kuntner C, Müller M, Langer O, Trauner M. PubMed
  • J Pharm Sci. 2016;105:854-63. Clearance prediction of HIV protease inhibitors in man: role of Hepatic uptake. De Bruyn T, Stieger B, Augustijns PF, Annaert PP. PubMed
  • Toxicol In Vitro. 2015;29:938-46. Polarized location of SLC and ABC drug transporters in monolayer-cultured human hepatocytes. Le Vee M, Jouan E, Noel G, Stieger B, Fardel O. PubMed
  • PLoS One. 2015;10:e0121232. Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract. Le Vee M, Jouan E, Stieger B, Lecureur V, Fardel O. PubMed
  • Biochem Pharmacol. 2015;98:649-58. Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate. Patik I, Kovacsics D, Német O, Gera M, Várady G, Stieger B, Hagenbuch B, Szakács G, Özvegy-Laczka C. PubMed
  • J Pharmacol Exp Ther. 2015;355:145-51. Octreotide inhibits the bilirubin carriers organic anion transporting polypeptides 1B1 and 1B3 and the multidrug resistance-associated protein 2. Visentin M, Stieger B, Merz M, Kullak-Ublick GA. PubMed
  • Biochem Pharmacol. 2015;98:703-17. Protein kinase C-dependent regulation of human hepatic drug transporter expression. Mayati A, Le Vee M, Moreau A, Jouan E, Bucher S, Stieger B, Denizot C, Parmentier Y, Fardel O. PubMed
  • Toxicol Sci. 2015;145:157-68. Comparative localization and functional activity of the main hepatobiliary transporters in HepaRG cells and primary human hepatocytes. Bachour-El Azzi P, Sharanek A, Burban A, Li R, Guével RL, Abdel-Razzak Z, Stieger B, Guguen-Guillouzo C, Guillouzo A. PubMed
  • Hepatology. 2015;62:207-19. Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. Slijepcevic D, Kaufman C, Wichers CG, Gilglioni EH, Lempp FA, Duijst S, de Waart DR, Elferink RP, Mier W, Stieger B, Beuers U, Urban S, van de Graaf SF. PubMed
  • Eur J Drug Metab Pharmacokinet. 2016;41:251-7. Efflux and uptake transporters involved in the disposition of bazedoxifene. Lušin TT, Mrhar A, Stieger B, Kristl A, Berginc K, Trontelj J. PubMed
  • Drug Metab Dispos. 2014;42:2007-15. Role of (drug) transporters in imaging in health and disease. Stieger B, Unadkat JD, Prasad B, Langer O, Gali H. PubMed
  • Curr Top Membr. 2014;73:205-32. Organic anion-transporting polypeptides. Stieger B, Hagenbuch B. PubMed
  • Mol Pharmacol. 2014;85:909-20. Differential effects of membrane cholesterol content on the transport activity of multidrug resistance-associated protein 2 (ABCC2) and of the bile salt export pump (ABCB11). Guyot C, Hofstetter L, Stieger B. PubMed
  • J Pharm Sci. 2014;103:1872-81. Confocal imaging with a fluorescent bile acid analogue closely mimicking hepatic taurocholate disposition. De Bruyn T, Sempels W, Snoeys J, Holmstock N, Chatterjee S, Stieger B, Augustijns P, Hofkens J, Mizuno H, Annaert P. PubMed
  • Drug Metab Dispos. 2014;42:675-84.The role of organic anion transporters in diagnosing liver diseases by magnetic resonance imaging. Pastor CM, Müllhaupt B, Stieger B. PubMed
  • Pflugers Arch. 2014;466:77-89. Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters. Anwer MS, Stieger B. PubMed
  • Biofactors. 2014;40:188-98. ATP-binding cassette transporters in liver. Wlcek K, Stieger B. PubMed
  • Toxicol In Vitro. 2013;27:1979-86. Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells. Le Vee M, Noel G, Jouan E, Stieger B, Fardel O. PubMed
  • Drug Metab Dispos. 2013;41:1522-8. Hepatocellular organic anion-transporting polypeptides (OATPs) and multidrug resistance-associated protein 2 (MRP2) are inhibited by silibinin. Wlcek K, Koller F, Ferenci P, Stieger B. PubMed
  • Clin Pharmacol Ther. 2013;94:95-112. In vitro methods to support transporter evaluation in drug discovery and development. Brouwer KL, Keppler D, Hoffmaster KA, Bow DA, Cheng Y, Lai Y, Palm JE, Stieger B, Evers R; International Transporter Consortium. PubMed
  • Clin Pharmacol Ther. 2013;94:52-63. Emerging transporters of clinical importance: an update from the International Transporter Consortium. Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L; International Transporter Consortium. PubMed
  • Mol Pharmacol. 2013;83:1257-67. Structure-based identification of OATP1B1/3 inhibitors. De Bruyn T, van Westen GJ, Ijzerman AP, Stieger B, de Witte P, Augustijns PF, Annaert PP. PubMed
  • Mol Aspects Med. 2013;34:396-412. The SLCO (former SLC21) superfamily of transporters.Hagenbuch B, Stieger B. PubMed
  • Eur J Pharm Sci. 2013;49:39-50. Functional expression and regulation of drug transporters in monolayer- and sandwich-cultured mouse hepatocytes. Noel G, Le Vee M, Moreau A, Stieger B, Parmentier Y, Fardel O. PubMed
  • Eur J Pharm Sci. 2013;48:767-74. Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes. Le Vee M, Jouan E, Stieger B, Fardel O. PubMed
  • Transl Res. 2012;160:298-308. Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment. Trdan Lušin T, Mrhar A, Stieger B, Kullak-Ublick GA, Marc J, Ostanek B, Zavratnik A, Kristl A, Berginc K, Delić K, Trontelj J. PubMed
  • J Transl Med. 2012;10:76.  Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene. Trdan Lušin T, Stieger B, Marc J, Mrhar A, Trontelj J, Zavratnik A, Ostanek B. PubMed
  • Mutagenesis. 2012;27:567-72. Genetic variations in bile acid homeostasis are not overrepresented in alcoholic cirrhosis compared to patients with heavy alcohol abuse and absent liver disease.Many N, Stickel F, Schmitt J, Stieger B, Soyka M, Frei P, Götze O, Müllhaupt B, Geier A. PubMed
  • Hepatology. 2012;56:209-18. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation. Jang JH, Rickenbacher A, Humar B, Weber A, Raptis DA, Lehmann K, Stieger B, Moritz W, Soll C, Georgiev P, Fischer D, Laczko E, Graf R, Clavien PA. PubMed
  • Eur J Pharmacol. 2012;675:1-5. The emerging role of transport systems in liver function tests. Stieger B, Heger M, de Graaf W, Paumgartner G, van Gulik T. PubMed
  • J Pharm Sci. 2011;100:5018-30. Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3. De Bruyn T, Fattah S, Stieger B, Augustijns P, Annaert P. PubMed
  • J Hepatol. 2011;55:1368-76. Interaction of bile salts with rat canalicular membrane vesicles: evidence for bile salt resistant microdomains. Guyot C, Stieger B. PubMed
  • Pharmacogenomics. 2011;12:611-31. Pharmacogenetics of drug transporters in the enterohepatic circulation. Stieger B, Meier PJ. PubMed

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Last update: June 2021